Information de reference pour ce titreAccession Number: | 00006976-199966010-00004.
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Author: | Weynand, B. a; Jonckheere, A. +,a; Frans, A. b; Rahier, J. a
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Institution: | (a)Department of Pathology and (b)Department of Internal Medicine, Division of Pneumology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Title: | |
Source: | Respiration. 66(1):14-19, 1999.
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Abstract: | : Long-term diabetes mellitus (DM) is characterized by widespread alterations of basal lamina (BL). The purpose of the present work was to verify whether the lung is also a target organ damaged in DM. Electron microscopy was performed on lung and kidney samples (autopsic material) from 6 diabetics and 6 control subjects studying the thickening of BL of different structures (alveolar epithelial BL, endothelial capillary BL, both fused BL, BL of the glomerular capillary endothelium and BL of the renal tubules). The results were as follows: (1) alveolar epithelial BL (mean +/- SD) = 121 +/- 11 nm in controls and 176 +/- 27 nm in diabetics (p < 0.01), (2) endothelial capillary BL = 164 +/- 14 nm in controls and 223 +/- 27 nm in diabetics (p < 0.001), (3) both BL fused = 222 +/- 23 nm in controls and 316 +/- 62 nm in diabetics (p < 0.01), (4) BL of the glomerular capillary endothelium = 374 +/- 44 nm in controls and 626 +/- 249 in diabetics (p < 0.05) and (5) BL of the renal tubules = 602 +/- 94 nm in controls and 1,083 +/- 376 nm in diabetics (p < 0.05). All parts of the lung are equally affected by DM. The thickening of BL is of the same magnitude in lung and kidney. There is no relationship between the thickening of the lung BL and the known duration and type of DM.
(C) 1999 S. Karger AG, Basel
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Author Keywords: | Diabetes mellitus; Basal lamina.
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References: | 1 Matthay MA: The lungs and endocrine disease 1921-1930; in Textbook of Respiratory Medicine. Philadelphia, Saunders, 1988, p 2102.
2 Barta L: Flexion contractures in a diabetic child. Eur J Pediatr 1980;135:101-102.
3 Cooper BG, Taylor R, Alberti KGMM, Gibson GJ: Lung function in patients with diabetes mellitus. Respir Med 1990;84:235-239.
4 Madacsy L: Joint and pulmonary changes in diabetes. Am J Dis Child 1987;141:244-245.
5 Montserrat JM, Cochrane GM, Wolf C, Picado C, Roca J, Agusti Vidal A: Ventilatory control in diabetes mellitus. Eur J Respir Dis 1985;67:112-117.
6 Oulhen P, Barthelemy L, Bellet-Barthas M, Darragon T: Contribution a l'etude de la fonction respiratoire du diabetique insulino-dependent. Rev Fr Mal Respir 1982;10:213-224.
7 Sandler M, Bumm AE, Stemont RI: Cross-section study of pulmonary function in patients with insulin-dependent diabetes mellitus. Am Rev Respir Dis 1987;135:223-229.
8 Schernthaner G, Haber P, Kummer R, Ludwig H: Lung elasticity in juvenile onset diabetes mellitus. Am Rev Respir Dis 1977;116:544-611.
9 Hamlin CR, Kahn RR, Luschini JH: Apparent accelerated aging of human collagen in diabetes mellitus. Diabetes 1975;24:902-904.
10 Caulfield JB: Dermal elastic tissue of diabetics. Beitr Pathol 1972;145:286-296.
11 Vracko R: Accumulation of basal lamina: A by-product of cell renewal; in Regnault F, Duhault D (eds): Cellular and Biochemical Aspects of Diabetic Retinopathy. INSERM Symposium No 7. Amsterdam, North Holland, 1978, pp 185-196.
12 Williamson DR, Vogeler N, Kilo C: The natural history of basement membrane disease in diabetes mellitus; in Malaisse WJ, Pirart J, Valame-Owen J (eds): Diabetes. International Congress Series No 312. New York, Excerpta Medica, 1974, pp 424-428.
13 Kodolova IM, Lysenko IV, Saltykov BB: Changes in the lung in diabetes mellitus. Arkh Patol 1982;44:35-40.
14 Vracko R, Thorning D, Huang TW: Basal lamina of alveolar epithelium and capillaries: Quantitative changes with aging and in diabetes mellitus. Am Rev Respir Dis 1979;120:973-983.
15 Snedecor GW, Cochran WG: Statistical Methods, ed 8. Ames, Iowa State University Press, 1989, p 503.
16 King GL, Banskota NK: Mechanisms of diabetic microvascular complications; in Kahn CR, Weir GC (eds): Joslin's Diabetes mellitus. Philadelphia, Lea & Febiger, 1994, pp 631-642.
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Language: | English.
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Document Type: | Clinical Investigations.
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Journal Subset: | Clinical Medicine. Life & Biomedical Sciences.
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ISSN: | 0025-7931
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NLM Journal Code: | 0137356, r8k
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DOI Number: | https://dx.doi.org/10.1159/00002...- ouverture dans une nouvelle fenêtre
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Annotation(s) | |