Information de reference pour ce titreAccession Number: | 00005712-199813020-00005.
|
Author: | Rose, C. 1; Michalak, A. 1; Pannunzio, P. 1; Therrien, G. 1; Quack, G. 2; Kircheis, G. 2; Butterworth, R. F. 1,3
|
Institution: | (1)Neuroscience Research Unit, Centre Hospitalier de l'Universite de Montreal (Campus Saint-Luc), Montreal, Quebec, Canada (2)Merz + Co., Frankfurt, Germany
|
Title: | L-Ornithine-L-Aspartate in Experimental Portal-Systemic Encephalopathy: Therapeutic Efficacy and Mechanism of Action.[Article]
|
Source: | Metabolic Brain Disease. 13(2):147-157, June 1998.
|
Abstract: | Strategies aimed at the lowering of blood ammonia remain the treament of choice in portal-systemic encephalopathy (PSE). L-ornithine-L-aspartate (OA) has recently been shown to be effective in the prevention of ammonia-precipitated coma in humans with PSE. These findings prompted the study of mechanisms of the protective effect of OA in portacaval-shunted rats in which reversible coma was precipitated by ammonium acetate administration (3.85 mmol/kg i.p.). OA infusions (300 mg/kg/h, i.v) offered complete protection in 12/12 animals compared to 0/12 saline-infused controls. This protective effect was accompanied by significant reductions of blood ammonia, concomitant increases of urea production and significant increases in blood and cerebrospinal fluid (CSF) glutamate and glutamine. Increased CSF concentrations of leucine and alanine also accompanied the protective effect of OA. These findings demonstrate the therapeutic efficacy of OA in the prevention of ammonia-precipitated coma in portacaval-shunted rats and suggest that this protective effect is both peripherally-mediated (increased urea and glutamine synthesis) and centrally-mediated (increased glutamine synthesis).
(C)1998 Kluwer Academic Publishers
|
Author Keywords: | Portal-systemic Encephalopathy; Hepatic Encephalopathy; Ammonia; L-ornithine-L-aspartate; Glutamine synthesis.
|
Language: | English.
|
Document Type: | RESEARCH ARTICLE: PDF Only.
|
Journal Subset: | Clinical Medicine.
|
ISSN: | 0885-7490
|
NLM Journal Code: | m9l, 8610370
|
Annotation(s) | |