Information de reference pour ce titreAccession Number: | 00004836-199806000-00009.
|
Author: | Minoli, Giorgio M.D.; Prada, Alberto M.D.; Schuman, Robert M.D.; Murnick, Daniel Ph.D.; Rigas, Basil M.D.
|
Institution: | From the Division of Gastroenterology (G.M.), Ospedale Valducce, Como, the Division of Gastroenterology (A.P.), Ospedale Rho, Milan, Italy; the Department of Medicine (R.S., B.R.), Cornell University Medical College, New York, New York; and the Department of Physics (D.M.), Rutgers University, Newark, New Jersey.
|
Title: | A Simplified Urea Breath Test for the Diagnosis of Helicobacter pylori Infection Using the LARA System.[Article]
|
Source: | Journal of Clinical Gastroenterology. 26(4):264-266, June 1998.
|
Abstract: | Helicobacter pylori, one of the most prevalent human pathogens, is associated with chronic gastritis, peptic ulcer disease, and possibly gastric cancer and primary gastric lymphoma. The need to treat these patients has necessitated the development of improved methods to diagnose H. pylori infection. We present the preliminary assessment of a 13C-urea breath test (UBT) in which the expired 13CO2 is detected in a rapid, simple, inexpensive way by the LARA (Laser Assisted Ratio Analyzer) System (Alimenterics, Inc., Morris Plains, NJ). Eighty-seven consecutive patients, examined for upper gastrointestinal symptoms, underwent endoscopy. H. pylori infection was established by antral biopsies and a rapid urease test (CLOtest). The UBT was performed between 2 and 24 hours after endoscopy. Of the 84 analyzable patients, 70 were found to be H. pylori-positive either by histology or by CLOtest. All 70 were positive by the LARA UBT, yielding a sensitivity of 100%. Fourteen patients were negative for H. pylori by histology and the CLOtest. Of these, 12 were negative by the LARA UBT and 2 were positive, yielding a specificity of 85.7%; because of the limitations of H. pylori detection by histology or urease assays, however, the specificity of the UBT may have been underestimated. Our study demonstrates the feasibility of a non-radioactive, rapid UBT based on the LARA system and suggests the need for its more detailed evaluation.
(C) Lippincott-Raven Publishers
|
Author Keywords: | Helicobacter pylori; Breath test; Urea; Gastritis.
|
References: | 1. Kuipers EJ. Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther 1977;1(suppl):71-88.
2. Forman D. Helicobacter pylori and gastric cancer. Scand J Gastroenterol 1996;215(suppl):48-51.
3. Anonymous. Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report European Helicobacter pylori Study Group. Gut 1997;41:8-13.
4. Migaud F. The most important diagnostic modalities for Helicobacter pylori, now and in the future. Eur J Gastroenterol Hepatol 1977;9(suppl 1):S13-15.
5. Atherton JC. Non-endoscopic tests in the diagnosis of Helicobacter pylori infection. Aliment Pharmacol Ther 1977;11(suppl 1):11-20.
6. Reilly TG, Poxon V, Sanders DS, Elliott TS, Walt RP. Comparison of serum, salivary, and rapid whole blood diagnostic tests for Helicobacter pylori and their validation against endoscopy-based tests. Gut 1977;40:454-8.
7. Peura DA, Pambianco DJ, Dye KR, Lind C, Frierson HF, Hoffman SR, Combs MJ, Guilfoyle E, Marshall BJ. Microdose 14C-urea breath test offers diagnosis in Helicobacter pylori in 10 minutes. Am J Gastroenterol 1996;91:233-88.
8. Klein PD, Malaty HM, Martin RF, Graham KS, Genta RM, Graham DY. Noninvasive detection of Helicobacter pylori infection in clinical practice: the 13C urea breath test. Am J Gastroenterol 1996;91:690-4.
9. Koletzko S, Haisch M, Seeboth I, Braden B, Hengels K, Koletzko B, Hering P. Isotope-selective non-dispersive infrared spectrometry for detection of Helicobacter pylori infection with 13C-urea breath test. Lancet 1995;345:961-2.
10. Murnick DE, Peer BJ. Laser-based analysis of carbon isotope ratios. Science 1994;263:945-7.
11. Thijs JC, Vanzwet AA, Thijs WJ, Oey HB, Karrenbelt A, Stellaard F, Luijt DS, Meyer BC, Kleibeuker JH. Diagnostic tests for Helicobacter pylori-a prospective evaluation of their accuracy, without selecting a single test as the gold standard. Am J Gastroenterol 1996;91:2125-9.
|
Language: | English.
|
Document Type: | Original Studies.
|
Journal Subset: | Clinical Medicine.
|
ISSN: | 0192-0790
|
NLM Journal Code: | ibg, 7910017
|
Annotation(s) | |
|
|