Information de reference pour ce titreAccession Number: | 00000652-199601000-00015.
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Author: | Ruperto, Nicolino; Giannini, Edward H.
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Institution: | Clinica Pediatrica, Universita di Pavia, IRCCS Policlinico `S Matteo', Pavia, Italy (N Ruperto). Williams S Rowe Division of Rheumatology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA (E H Giannini) Correspondence to: Dr Edward H Giannini, Children's Hospital Medical Center, 3333 Burnet Avenue, Pav 2-129, Cincinnati, OH 45229-3039, USA. Accepted for publication 13 September 1995
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Title: | Redundancy of conventional articular response variables used in juvenile chronic arthritis clinical trials.[Report]
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Source: | Annals of the Rheumatic Diseases. 55(1):73-75, January 1996.
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Abstract: | Objective: To estimate the degree of redundancy among articular response variables used routinely in juvenile chronic arthritis (JCA) clinical trials.
Methods: We obtained data from a large, computerised databank holding information from multiple clinical trials in children with JCA to determine Pearson correlation coefficients for changes from baseline values in articular response variables. All 508 JCA patients who entered the analysis of efficacy of the original trials were included in the present study. An r value of 0.7 or greater was considered evidence of colinearity.
Results: When changes in joint counts of articular manifestations were compared with changes in the respective severity scores (for example swollen joint count versus swelling severity score), the r values were always greater than or equal to 0.7. Three articular response variables related to the assessment of pain are all highly correlated with each other. The number of joints with active arthritis was correlated with the number of joints with swelling and the swelling score. Change in the overall severity score was highly correlated (r greater than or equal to 0.7) with change in nearly all articular response variables.
Conclusions: Many endpoints reported in JCA trials are redundant, especially counts and scores of the same articular measure. Eliminating redundant variables would provide the same information with less complexity, and decrease the probability of statistical error and ambiguous results.
(Ann Rheum Dis 1996; 55: 73-75)
Copyright (C) 1996 by the Annals of the Rheumatic Diseases
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Language: | English.
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Document Type: | Extended Report.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0003-4967
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NLM Journal Code: | 0372355, 62w
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