Information de reference pour ce titreAccession Number: | 00000605-199312010-00007.
|
Author: | Fine, Howard A.; Mayer, Robert J.
|
Institution: | From the Dana-Farber Cancer Institute, The Brain Tumor Center, The Brigham and Women's Hospital, and Harvard Medical School, Boston Massachusetts. Requests for Reprints: Howard A. Fine, MD, Division of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115.
|
Title: | |
Source: | Annals of Internal Medicine. 119(11):1093-1104, December 1, 1993.
|
Abstract: | Objective: To compare the pathogenesis, clinical presentation, therapy, and prognosis of primary central nervous system lymphoma in immunocompetent persons with these characteristics of the disease in patients with AIDS.
Data Sources and Extraction: All English-language papers published between 1980 and 1992 dealing with either lymphoma and the central nervous system or AIDS were reviewed. Patient characteristics, clinical presentation, histologic findings, and treatment and survival data were extracted from each case report and review.
Data Synthesis: Data were available on 792 patients (from 40 reported series) with non-AIDS-associated primary central nervous system lymphoma and 315 patients (from 32 series) with AIDS-associated primary central nervous system lymphoma. Patients with AIDS initially consulted a physician more often when they had global neurologic symptoms compared with patients without AIDS, with more than 50% of the lesions on computed tomographic (CT) scans in patients with AIDS being ring-enhancing and multifocal, a pattern rarely described in immunocompetent patients. The overall survival of the patients without AIDS was 18.9 months compared with 2.6 months for patients with AIDS, with substantial differences remaining even for subgroups of patients similarly treated with radiation and chemotherapy.
Conclusion: Primary central nervous system lymphoma is probably a substantially different disease in persons with and without AIDS with regard to patient characteristics, clinical and radiographic presentation, and prognosis. Recent advances in the treatment of this disease in patients without AIDS have not largely affected patients with AIDS. Substantial improvements in survival in these patients await advances in controlling their human immunodeficiency virus-associated disease.
(C) 1993 American College of Physicians
|
References: | 1. Bleyer WA, Byrne TN. Leptomeningeal cancer in leukemia and solid tumors. Curr Pobl Cancer. 1988;12:181-238.
2. Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972;29:252-60.
3. Jellinger K, Radaskiewicz TH, Slowik F. Primary malignant lymphomas of the central nervous system in man. Acta Neuropathol (Berl). 1975;6(Suppl):95-102.
4. Zimmerman HM. Malignant lymphomas of the nervous system. Acta Neuropathol (Berl). 1975;6(Suppl):69-74.
5. Hanbery JW, Dugger GS. Perithelial sarcoma of the brain. A clinicopathologic study of thirteen cases. Arch Neurol Psychiatry. 1964;74:732-61.
6. Barnett LB, Schwartz E. Cerebral reticulum cell sarcoma after multile renal transplants. J Neurol Neurosurg Psychiatry. 1974;37: 966-70.
7. Benedek L, Juba A. Uber das microgliom. Dtsh Z Nervehnheilk. 1941;152:159-69.
8. Schaumburg HH, Plank CR, Adams RD. The reticulum cell sarcoma-microglioma group of brain tumors. Brain. 1972;95:199-212.
9. Schneck SA, Penn I. De-novo brain tumours in renal-transplant recipients. Lancet. 1972;1:983-6.
10. Model LM. Primary reticulum cell sarcoma of the brain in Wiskott-Aldrich syndrome. Report of a case. Arch Neurol. 1977;34:633-5.
11. Snider WD, Simpson DM, Aronyk KE, Nielsen SL. Primary lymphoma of the central nervous system associated with acquired immune-deficiency syndrome (Letter). N Engl J Med. 1983;308:45.
12. Eby NL, Grufferman S, Flannelly CM, Schold SC Jr, Vogel FS, Burger PC. Increasing incidence of primary brain lymphoma in the U.S. Cancer. 1988;62:2461-5.
13. Henry JM, Heffner RR Jr, Dillard SH, Earle KM, Davis RL. Primary malignant lymphomas of the central nervous system. Cancer. 1974;34:1293-302.
14. Littman P, Wang CC. Reticulum cell sarcoma of the brain. A review of the literature and a study of 19 cases. Cancer. 1975;35: 1412-20.
15. Sagerman RH, Cassady JR, Chang CH. Radiation therapy for intracranial lymphoma. Radiology. 1967;88:552-4.
16. Hochberg FH, Miller DC. Primary central nervous system lymphoma. J Neurosurg. 1988;68:835-53.
17. O'Neill BP, Illig JJ. Primary central nervous system lymphoma. Mayo Clin Proc. 1989;64:1005-20.
18. DeAngelis LM, Yahalom J, Thaler HT, Kher U. Combined modality therapy for primary CNS lymphoma. J Clin Oncol. 1992;10: 635-43.
19. Neuwelt EA, Frenkel EP, Gumerlock MK, Braziel R, Dana B, Hill SA. Developments in the diagnosis and treatment of primary CNS lymphoma. Cancer. 1986;58:1609-20.
20. Kawakami Y, Tabuchi K, Ohnishi R, Asari S, Nishimoto A. Primary central nervous system lymphoma. J Neurosurg. 1985;62: 522-7.
21. Freeman CR, Shustik C, Brisson ML, Meagher-Villemure K, Dylewski I. Primary malignant lymphoma of the central nervous system. Cancer. 1986;58:1106-11.
22. Mendenhall NP, Thar TL, Agee OF, Harty-Golder B, Ballinger WE, Million RR. Primary lymphoma of the central nervous system. Cancer. 1983;52:1993-2000.
23. Gonzalez DG, Schuster-Uitterhoeve AL. Primary non-Hodgkin's lymphoma of the central nervous system. Cancer. 1983;51:2048-52.
24. Grant JW, Gallagher PJ, Jones DB. Primary cerebral lymphoma. Arch Pathol Lab Med. 1986;110:897-901.
25. Murray K, Kun L, Cox J. Primary malignant lymphoma of the central nervous system. J Neurosurg. 1986;65:600-7.
26. Di Marco A, Rosta L, Campostrini F, Bonetti A, Palazzi M, Garusi G. The role of radiation therapy in the management of primary non-Hodgkin's lymphomas of the central nervous system: clinical study of 10 cases. Tumori. 1986;72:565-73.
27. Hobson DE, Anderson BA, Carr I, West M. Primary lymphoma of the central nervous system: Manitoba experience and literature review. Can J Neurol Sci. 1986;13:55-61.
28. Bertoncelli C, Zigrossi P, Campanini M, Erbetta M, Malinverni A, Angeli G, et al. Primary lymphoma of the central nervous system. A clinical and immunohistological study of 8 patients. Haematologica. 1987;72:137-42.
29. Pollack IF, Lunsford LD, Flickinger JC, Dameshek HL. Prognostic factors in the diagnosis and treatment of primary central nervous system lymphoma. Cancer. 1989;63:939-47.
30. McLaughlin P, Velasquez WS, Redman JR, Yung WK, Hagemeister FB, Rodriguez MA, et al. Chemotherapy with dexamethasone, high-dose cytarabine, and cisplatin for parenchymal brain lymphomas. J Natl Cancer Inst. 1988;80:1408-12.
31. Allegranza A, Mariani C, Giardini R, Brambilla MC, Boeri R. Primary malignant lymphomas of the central nervous system: a histological and immunohistological study of 12 cases. Histopathology. 1984;8:781-91.
32. Stewart DJ, Russell N, Atack EA, Quarrington A, Stolbach L. Cyclophosphamide, doxorubicin, vincristine, and dexamethasone in primary lymphoma of the brain: a case report. Cancer Treat Rep. 1983;67:287-91.
33. Cohen IJ, Vogel R, Matz S, Weitz R, Mor C, Stern S, Zaizov R. Successful non-neurotoxic therapy (without radiation) of a multifocal primary brain lymphoma with a methotrexate, vincristine, and BCNU protocol (DEMOB). Cancer. 1986;57:6-11.
34. Vakili ST, Muller J, Shidnia H, Campbell RL. Primary lymphoma of the central nervous system: a clinico-pathologic analysis of 26 cases. J Surg Oncol. 1986;33:95-102.
35. Schiffer D, Chio A, Giordana MT, Novero D, Palestro G, Soffietti R, et al. Primary lymphomas of the brain: a clinicopathologic review of 37 cases. Tumori. 1987;73:585-92.
36. Loeffler JS, Ervin TJ, Mauch P, Skarin A, Weinstein HJ, Canellos G, et al. Primary lymphomas of the central nervous system: patterns of failure and factors that influence survival. J Clin Oncol. 1985;3:490-4.
37. Yasunaga T, Takahashi M, Uozumi H, Takada C, Kawano S, Baba Y, et al. Radiation therapy of primary malignant lymphoma of the brain. Acta Radiol (Oncol). 1986;25:23-8.
38. Woodman R, Shin K, Pineo G. Primary non-Hodgkin's lymphoma of the brain. Medicine (Baltimore). 1985;64:425-30.
39. Michalski JM, Garcia DM, Kase E, Grigsby PW, Simpson JR. Primary central nervous system lymphoma: analysis of prognostic variables and patterns of treatment failure. Radiology. 1990;176: 855-60.
40. Pittman KB, Olweny CL, North JB, Blumbergs PC. Primary central nervous system lymphoma. Oncology. 1991;48:184-7.
41. Neuwelt EA, Goldman DL, Dahlborg SA, Crossen J, Ramsey F, Roman-Goldstein S, et al. Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: prolonged survival and presentation of cognitive function. J Clin Oncol. 1991;9:1580-90.
42. Rampen FH, van Andel JG, Sizoo W, van Unnik AM. Radiation therapy in primary non-Hodgkin's lymphomas of the CNS. Eur J Cancer. 1980;16:177-84.
43. Berry MP, Simpson WJ. Radiation therapy in the management of primary malignant lymphoma of the brain. Int J Radiat Oncol Biol Phys. 1981;7:55-9.
44. Spillane JA, Kendall BE, Moseley IF. Cerebral lymphoma: clinical radiological correlation. J Neuro Neurosurg Psychiatry. 1982;45: 199-208.
45. Merkel KH, Hansmann ML. Primary non-Hodgkin's lymphomas of the central nervous system. Pathol Res Pract. 1986;181:430-3.
46. Watanabe M, Tanaka R, Takeda N, Wakabayashi K, Takahashi H. Correlation of computed tomography with the histopathology of primary malignant lymphoma of the brain. Neuroradiology. 1992; 34:36-42.
47. Bogdahn U, Bogdahn S, Mertens HG, Dommasch D, Wodarz R, Wunsch PH, et al. Primary non-Hodgkin's lymphomas of the CNS. Acta Neurol Scand. 1986;73:602-14.
48. Sagerman RH, Collier CH, King GA. Radiation therapy of microgliomas. Radiology. 1983;149:567-70.
49. Helle TL, Britt RH, Colby TV. Primary lymphomas of the central nervous system. J Neurosurg. 1984;60:94-103.
50. Frank G, Ferracini R, Spagnolli F, Frank F, Gaist G, Lorenzini P, Ricci R. Primary intracranial lymphomas. Surg Neurol. 1985;23: 3-8.
51. Spaun E, Midholm S, Pederson NT, Ringsted J. Primary malignant lymphoma of the central nervous system. Surg Neurol. 1985;24: 646-50.
52. Remick SC, Diamond C, Migliozzi JA, Solis O, Wagner H, Haase R, et al. Primary central nervous system lymphoma in patients with and without the acquired immune deficiency syndrome. Medicine (Baltimore). 1990;69:345-60.
53. Casadei GP, Gambacorta M. A clinicopathological study of seven cases of primary high-grade malignant non-Hodgkin's lymphoma of the central nervous system. Tumori. 1985;71:501-7.
54. So YT, Beckstead JH, Davis RL. primary central nervous system lymphoma in acquired immune deficiency syndrome: a clinical and pathological study. Ann Neurol. 1986;20:566-72.
55. Poon T, Matoso I, Tchertkoff V, Weitzner I Jr, Gade M. CT features of primary cerebral lymphoma in AIDS and non-AIDS patients. J Comp Assist Tomogr. 1989;13:6-9.
56. Formenti SC, Gill PS, Lean E, Rarick M, Meyer PR, Boswell W, et al. Primary central nervous system lymphoma in AIDS. Cancer. 1989;63:1101-7.
57. Loureiro C, Gill PS, Meyer PR, Rhodes R, Rarick M, Levine AM. Autopsy findings in AIDS-related lymphoma. Cancer. 1988;62: 735-9.
58. Levine AM, Sullivan-Halley J, Pike MC, Rarick MU, Loureiro C, et al. Human immunodeficiency virus-related lymphoma. Cancer. 1991;68:2466-73.
59. MacMahon EM, Glass JD, Hayward SD, Mann RB, Becker PS, Charache P, et al. Epstein-Barr virus in AIDS-related primary central nervous system lymphoma. Lancet. 1991;338:969-81.
60. DeWeese TL, Hazuka MB, Hommel DJ, Kinzie JJ, Daniel WE. AIDS-related non-Hodgkin's lymphoma: the outcome and efficacy of radiation therapy. Int J Radiat Oncol Biol Phys. 1991;20:803-8.
61. Goldstein JD, Zeifer B, Chao C, Moser FG, Dickson DW, Hirschfeld AD, et al. CT appearance of primary CNS lymphoma in patients with acquired immunodeficiency syndrome. J Comp Assist Tomogr. 1991;15:39-44.
62. Dina TS. Primary central nervous system lymphoma versus toxoplasmosis in AIDS. Radiology. 1991;179:823-8.
63. Baumgartner JE, Rachlin JR, Beckstead JH, Meeker TC, Levy RM, Wara WM, et al. Primary central nervous system lymphomas: natural history and response to radiation therapy in 55 patients with acquired immunodeficiency syndrome. J Neurosurg. 1990;73: 206-11.
64. Chappell ET, Guthrie BL, Orenstein J. The role of stereotactic biopsy in the management of HIV-related focal brain lesions. Neurosurgery. 1992;30:825-9.
65. Goldstein JD, Dickson DW, Moser FG, Hirschfeld AD, Freeman K, Llena JF, et al. Primary central nervous system lymphoma in acquired immune deficiency syndrome. Cancer. 1991;67:2756-65.
66. Ziegler JL, Beckstead JA, Volberding PA, Abrams DI, Levine AM, Lukes RJ, et al. Non- Hodgkin's lymphoma in 90 homosexual men. N Engl J Med. 1984;311:565-70.
67. DiCarlo EF, Amberson JB, Metroka CE, Ballard P, Moore A, Mouradian JA. Malignant lymphomas and the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1986;110:1012-6.
68. Nakleh RE, Manivel JC, Hurd D, Sung JH. Central nervous system lymphomas. Arch Pathol Lab Med. 1989;113:1050-6.
69. Pitlick SD, Fainstein V, Bolivar R, Guarda L, Rios A, Mansell PA, et al. Spectrum of central nervous system complications in homosexual men with acquired immune deficiency syndrome (Letter). J Infect Dis. 1983;148:771-2.
70. Italian Cooperative Group for AIDS-Related Tumors. Malignant lymphomas in patients with or at risk for AIDS in Italy. J Natl Cancer Inst. 1988;80:855-60.
71. McArthur JC. Neurologic manifestations of AIDS. Medicine (Baltimore). 1987;66:407-37.
72. Capanna AH, LaMancusa J Jr, Erculei F, Fathie K, Christenson P, Mulkey DA. Primary cerebral lymphoma in two consortial partners afflicted with acquired immune deficiency syndrome. Neurosurgery. 1987;21:920-3.
73. Mernick MH, Malamud SC, Haubenstock A, Rimarenko S, Zalusky R. Non-Hodgkin's lymphoma in AIDS: report of 11 cases and literature review. Mt Sinai J Med. 1986;53:664-7.
74. Snow RB, Lavyne MH. Intracranial space-occupying lesions in acquired immune deficiency syndrome patients. Neurosurgery. 1985;16:148-53.
75. Koppel BS, Wormser GP, Tuchman AJ, Maayan S, Hewlett D Jr, Daras M. Central nervous system involvement in patients with acquired immune deficiency syndrome (AIDS). Acta Neurol Scand. 1985;71:337-53.
76. Gill PS, Levine AM, Meyer PR, Boswell WD, Burkes RL, Parker JW, et al. Primary central nervous system lymphoma in homosexual men. Am J Med. 1985;78:742-8.
77. Anders KH, Latta H, Chang BS, Tomiyasu U, Quddusi AS, Vinters HV. Lymphomatoid granulomatosis and malignant lymphoma of the central nervous system in the acquired immunodeficiency syndrome. Hum Pathol. 1989;20:326-34.
78. Kaplan MH, Susin B, Pahwa G, Fetten J, Allen SL, Lichtman S, et al. Neoplastic complications of HTLV-III infection. Am J Med. 1987;82:389-96.
79. Kalter SP, Riggs SA, Cabanillas F, Butler JJ, Hagemeister FB, Mansell PW, et al. Aggressive non-Hodgkin's lymphoma in immunocompromised homosexual males. Blood. 1985;66:655-9.
80. Lowenthal DA, Straus DJ, Campbell SW, Gold JW, Clarkson BD, Koziner B. AIDS-related lymphoid neoplasia: the Memorial Hospital experience. Cancer. 1988;61:2325-37.
81. Ahmed T, Wormser GP, Stahl RE, Mamtani R, Cimino J, Glasser M, et al. Malignant lymphomas in a population at risk for acquired immune deficiency syndrome. Cancer. 1987;60:719-23.
82. Knowles DM, Chamulak GA, Subar M, Burke JS, Dugan M, Wernz J, et al. Lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1988;108:744-53.
83. Kaplan LD, Abrams DI, Feigal E, McGrath M, Kahn J, Neville P, et al. AIDS-associated non-Hodkin's lymphoma in San Francisco. JAMA. 1989;261:719-24.
84. Song SK, Schwartz IS, Breakstone BA. Lymphoproliferative disorder of the central nervous system in AIDS. Mt Sinai J Med. 1986;53:686-9.
85. Pluda M, Yarchoan R, Jaffe ES, Feuerstein IM, Solomon D, Steinberg SM, et al. Development of non-Hodgkin lymphoma in a cohort of patients with severe human immunodeficiency virus (HIV) infection on long-term antiretroviral therapy. Ann Intern Med. 1990;113:276-82.
86. Shibata S. Sites of origin of primary intracerebral malignant lymphoma. Neurosurgery. 1989;25:14-9.
87. Penn I. Development of cancer as a complication of clinical transplantation. Transplant Proc. 1977;9:1121-7.
88. Weintraub J, Warnke RA. Lymphoma in cardiac allotransplant recipients. Clinical and histological features and immunological phenotype. Transplantation. 1982;33:347-51.
89. Hochberg FH, Miller G, Schooley RT, Hirsch MS, Feorino P, Henle W. Central-nervous-system lymphoma related to Epstein-Barr virus. N Engl J Med. 1983;309:745-8.
90. Bashir RM, Haris NL, Hochberg FH, Singer RM. Detection of Epstein-Barr virus in CNS lymphomas by in-situ hybridization. Neurology. 1989;39:813-7.
91. Ho M, Miller G, Atchison RW, Breinig MK, Dummer JS, Andiman W, et al. Epstein-Barr virus infections and DNA hybridization studies in posttransplant lymphoma and lymphoproliferative lesions: the role of primary infection. J Infect Dis. 1985;152:876-86.
92. Ho M, Jaffe R, Miller G, Breinig MK, Dummer JS, Makowka L, et al. The frequency of Epstein-arr virus infection and associative lymphoproliferative syndrome after transplantation and its manifestations in children. Transplantation. 1988;45:719-27.
93. Bignon YJ, Clavelou P, Ramos F, Jouvet A, Tommasi M, Tournilhac M, et al. Detection of Epstein-Barr virus sequences in primary brain lymphoma without immunodeficiency. Neurology. 1991;41: 1152-3.
94. Magrath I. Clinical and pathological features of Burkitts' lymphoma and their relevance to treatment. In: Levine PH, Ablash DV, Pearson GR, et al. Epstein-Barr Virus and Associated Diseases. Boston: Martinus, Nijhoff; 1985:631-43.
95. Klein G. Lymphoma development in mice and human: diversity of inhibition is followed by convergent cytogenetic evaluation. Proc Natl Acad Sci USA. 1979;76:2442-6.
96. Duggan DB, Ehrlich GD, Davey FP, Kwok S, Sninsky J, Goldberg J, et al. HTLV-I-induced lymphoma mimicking Hodgkin's disease: diagnosis by poymerase chain reaction amplification of specific HTLV-1 sequences in tumor DNA. Blood. 1988;71:1027-32.
97. Ezrin-Waters C, Klein M, Deck J, Lang AE. Diagnostic importance of immunological markers in lymphoma involving the central nervous system. Ann Neurol. 1984;16:668-72.
98. Jones GR, Mason WH, Fishman LS, DeClerck YA. Primary central nervous system lymphoma without intracranial mass in a child. Diagnosis by documentation of monoclonality. Cancer. 1985;56: 2804-8.
99. Anders KH, Guerra WF, Tomiyasu U, Verity MA, Vinters HV. The neuropathology of AIDS. Am J Pathol. 1986;124:537-58.
100. Snider WD, Simpson DM, Nielsen S, Gold WJ, Metroka CE, Posner JB. Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients. Ann Neurol. 1983;14:403-18.
101. Bush RS, Gaspodarowicz M, Sturgeon J, Alison R. Radiation therapy of localized non-Hodgkin's lymphoma. Cancer Treat Rep. 1977;61:1129-36.
102. Fuks Z, Kaplan HJ. Recurrence rates following radiation therapy of nodular and diffuse malignant lymphomas. Radiology. 1973;108: 675-84.
103. Hochberg FH, Loeffler JS, Prados M. The therapy of primary brain lymphoma. J Neurol Oncol. 1991;10:191-201.
104. Singh A, Strobos RJ, Singh BM, Rothballer AB, Reddy V, Puljic S, et al. Steroid-induced remissions in CNS lymphoma. Neurology. 1982;32:1267-71.
105. Vaquero J, Martinez R, Rossi E, Lopez R. Primary cerebral lymphoma: the "ghost tumor." Case report. J Neurosurg. 1984;60: 174-6.
106. Ott RJ, Brada M, Flower MA, Babich JW, Cherry SR, Deehan BJ. Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma. Eur J Cancer. 1991;27:1356-61.
107. Skarin AT, Zuckerman KS, Pitman SW, Rosenthal DS, Moloney W, Frei E 3d, et al. High- dose methotrexate with folinic acid in the treatment of advanced non-Hodgkin lymphoma including CNS involvement. Blood. 1977;50:1039-47.
108. Herbst KD, Corder MP, Justice GR. Successful therapy with methotrexate of a multicentric mixed lymhoma of the central nervous system. Cancer. 1976;38:1476-8.
109. Ervin T, Canellos GP. Successful treatment of recurrent primary central nervous system lymphoma with high-dose methotrexate. Cancer. 1980;45:1556-7.
110. Abelson HT, Kufe DW, Skarin AT, Major P, Ensminger W, Beardsley GP, et al. Treatment of central nervous system tumors with methotrexate. Cancer Treat Rep. 1981;65:137-40.
111. Gabbai AA, Hochberg FH, Linggood RM, Bashir R, Hotleman K. High-dose methotrexate therapy of non-AIDS primary brain lymphoma. J Neurosurg. 1989;70:190-4.
112. Levine AM. Acquired immunodeficiency syndrome-related lymphoma. Blood. 1992;80:8-20.
|
Language: | English.
|
Document Type: | Reviews.
|
Journal Subset: | Clinical Medicine.
|
ISSN: | 0003-4819
|
NLM Journal Code: | 0372351, 5a6
|
Annotation(s) | |
|
|