Information de reference pour ce titreAccession Number: | 00005531-199305150-00006.
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Author: | Lampeter, Eberhard F.; Homberg, Michael; Quabeck, Klaus; Schaefer, Ulrich W.; Wernet, Peter; Bertrams, Jorg; Grosse-Wilde, H.; Gries, F. Arnold; Kolb, Hubert.
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Institution: | Diabetes Research Institute, Dusseldorf (E. F. Lampeter, MD, M. Homberg, MD, Prof F. A. Gries, MD, Prof H. Kolb, PhD); Department of Bone Marrow Transplantation, University of Essen, Essen (K. Quabeck, MD, Prof U. W. Schaefer, MD); Institute for Haemostasis and Blood Transfusion, University of Dusseldorf (P. Wernete, MD); Institute for Immunology, University of Essen (Prof H. Grosse - Wilde, MD); Department of Laboratory Medicine, Elisabeth Hospital, Essen, Germany (Prof J. Bertrams, MD). Correspondence: Dr E. F. Lampeter, Diabetes-Forschungsinstitut, Auf'm Hennekamp 65, W-4000 Dusseldorf 1, Germany.
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Title: | Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation.[Report]
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Source: | Lancet. 341(8855):1243-1244, May 15, 1993.
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Abstract: | Insulin-dependent diabetes was observed in a woman, aged 29, 4 years after transplantation of bone marrow from her HLA-identical brother with insulin-dependent diabetes. Both had classic symptoms and insulin dependency from onset. At diagnosis of diabetes the recipient was positive for high-titre islet cell antibodies (ICA) whereas she had been ICA negative before transplantation. Chromosomal analyses verified that all circulating leucocytes were of male donor type. These findings suggest transfer of insulin-dependent diabetes by bone marrow cells and confirm the immune nature of the disease.
Copyright. (C) The Lancet Ltd, 1993.
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Language: | English.
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Document Type: | Short Report.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0140-6736
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NLM Journal Code: | 2985213r, l0s, 0053266
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Annotation(s) | |
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