Information de reference pour ce titreAccession Number: | 00000465-199503000-00016.
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Author: | Biederman, Joseph; Faraone, Stephen V.; Mick, Eric; Spencer, Thomas; Wilens, Timothy; Kiely, Kathleen; Guite, Jessica; Ablon, J. Stuart; Reed, Ellen; Warburton, Rebecca
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Institution: | Received Jan. 21, 1994; revisions received April 26 and Aug. 5, 1994; accepted Sept. 1, 1994. From the Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital; Harvard Medical School, Boston; and the Psychiatry Service of the Brockton VA Medical Center, Brockton, Mass. Address reprint requests to Dr. Biederman, Pediatric Psychopharmacology Unit (WACC 725), Massachusetts General Hospital, 15 Parkman St., Boston, MA 02114.
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Title: | High Risk for Attention Deficit Hyperactivity Disorder Among Children of Parents With Childhood Onset of the Disorder: A Pilot Study.[Article]
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Source: | American Journal of Psychiatry. 152(3):431-435, March 1995.
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Abstract: | Objective: Although well-documented in clinical and epidemiological studies of attention deficit hyperactivity disorder (ADHD) in children, the familial nature of the adult syndrome has not been well investigated. One approach to evaluate the familial nature of adult ADHD is through a high-risk design aimed at estimating the risk for the disorder in children of parents with childhood-onset ADHD. Method: Children at risk for ADHD were ascertained from the study group of 84 referred adults with clinical diagnoses of childhood onset of the disorder, confirmed by structured interviews. Diagnostic information on the disorder was derived from the ADHD module of the Schedule for Affective Disorders and Schizophrenia for School Age Children--Epidemiologic Version, supplemented with information regarding treatment for ADHD for the affected child and school history including repeated grades, placement in special classes, and tutoring. Results: Of the 84 children at risk, 48 (57%) met criteria for ADHD. The rate of the disorder in children of adults with the disorder was significantly higher than the previously reported rate of ADHD among siblings of children with the disorder. Of the 48 ADHD children of parents with the disorder, 36 (75%) were treated for it. The rates of school failure were almost identical to those previously reported in a group of referred children and adolescents with ADHD. Conclusions: These results support the validity of the adult diagnosis of ADHD and suggest that the adult form of this disorder may have stronger familial etiological risk factors than its pediatric form. If these results are confirmed, families selected through adult probands with ADHD might be especially useful for testing genetic hypotheses about the disorder. (Am J Psychiatry 1995; 152:431-435)
Copyright (C) 1995 American Psychiatric Association.
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Language: | English.
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Document Type: | Regular Articles.
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Journal Subset: | Clinical Medicine. Behavioral & Social Sciences.
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ISSN: | 0002-953X
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NLM Journal Code: | 0370512, 3vg
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Annotation(s) | |
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