Information de reference pour ce titreAccession Number: | 00000816-199509000-00014.
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Author: | Murphy, Jerome V. MD; Hornig, Gregory MD; Schallert, Gloria RN
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Institution: | From the Sections of Neurology and Neurosurgery, Children's Mercy Hospital, Kansas City, Mo.
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Title: | Left Vagal Nerve Stimulation in Children With Refractory Epilepsy: Preliminary Observations.[Article]
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Source: | Archives of Neurology. 52(9):886-889, September 1995.
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Abstract: | Objective: To observe the tolerance and efficacy of periodic left vagal nerve stimulation in a group of children with medically intractable epilepsies.
Design: A vagal nerve stimulator (Cyberonics Inc, Webster, Tex) was implanted in 12 children with medically and surgically refractory epilepsies. These children were followed up for 2 to 14 months.
Outcome Measurements: (1) The number of seizures recorded during the final month of observation was compared with the number recorded during the month before the implantation of the vagal nerve stimulator. (2) Parents were asked to com- pare overall status of their child, relative to the period prior to using the vagal nerve stimulator, on a global rating scale. (3) The number of antiepileptic drugs at the last visit was compared with the number before the use of this device. (4) Adverse events were recorded.
Results: Five of the 12 patients had a greater than 90% reduction in the number of monthly seizures. Global evaluation scores indicated that there were no deteriorations from baseline and that there was a considerable number with improved status. Four patients were able to reduce the number of antiepileptic drugs used. No significant adversities were noted.
Conclusions: The vagal nerve stimulator is well tolerated in children with intractable epilepsies, and it may have a role in their medical management. We were unable to determine specific epilepsies or seizures that were sensitive to this intervention.
(Arch Neurol. 1995;52:886-889)
Copyright 1995 by the American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use. American Medical Association, 515 N. State St, Chicago, IL 60610.
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Author Keywords: | Anticonvulsants; Child; Epilepsy; Equipment and Supplies; Seizures; Vagus Nerve.
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Language: | English.
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Document Type: | Original Contribution.
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Journal Subset: | Clinical Medicine. Behavioral & Social Sciences.
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ISSN: | 0003-9942
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NLM Journal Code: | 80k, 0372436
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Annotation(s) | |