Information de reference pour ce titreAccession Number: | 00076734-198709000-00064.
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Author: | Johnson, David E. *; Lockatell, Virginia C.; Hall-Craigs, Mary; Mobley, Harry L.T.; Warren, John W.
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Institution: | From the Infectious Diseases Laboratory, Veterans Administration Medical Center, and the Division of Infectious Diseases and Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland
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Title: | |
Source: | Journal of Urology. 138(3):632-635, September 1987.
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Abstract: | Providencia stuartii, a frequent and persistent isolate from the urinary tract of chronically catheterized elderly patients, is multiply antibiotic resistant and may cause fatal bacteremia in those patients. We studied P. stuartii strains in rats and mice to determine differences in uropath-ogenicity. Strains studied varied in expression of factors which contribute to pathogenicity of other bacterial species. Urinary tract responses following challenge with P. stuartii strain HO (factors expressed) were similar to responses reported for uropathogenic E. coli strains both in bacterial persistence and histologic change. In animals similarly challenged with P. stuartii strain RO (factors not expressed), responses were similar to those reported for non-uropathogenic E. coli strains. Results indicate that: a) animal model studies may be useful in differentiating P. stuartii strains based on uropathogenicity, b) P. stuartii uropathogenicity may be related to identifiable factors associated with virulence in other species, and c) the CBA mouse model appears to be the most suitable for studies of P. stuartii uropathogenicity. (J. Urol., 138: 632-635, 1987)
(C) 1987 by the American Urological Association, Inc.
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Language: | English.
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Document Type: | Articles: PDF Only.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0022-5347
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DOI Number: | https://dx.doi.org/10.1016/S0022...- ouverture dans une nouvelle fenêtre
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