Information de reference pour ce titreAccession Number: | 00007529-201909270-00018.
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Author: | Camp, J. Gray 1; Platt, Randall 2; Treutlein, Barbara 2,*
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Institution: | (1)Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland. (2)Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
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Title: | |
Source: | Science. 365(6460):1401-1405, September 27, 2019.
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Abstract: | The cumulative activity of all of the body's cells, with their myriad interactions, life histories, and environmental experiences, gives rise to a condition that is distinctly human and specific to each individual. It is an enduring goal to catalog our human cell types, to understand how they develop, how they vary between individuals, and how they fail in disease. Single-cell genomics has revolutionized this endeavor because sequencing-based methods provide a means to quantitatively annotate cell states on the basis of high-information content and high-throughput measurements. Together with advances in stem cell biology and gene editing, we are in the midst of a fascinating journey to understand the cellular phenotypes that compose human bodies and how the human genome is used to build and maintain each cell. Here, we will review recent advances into how single-cell genomics is being used to develop personalized phenotyping strategies that cross subcellular, cellular, and tissue scales to link our genome to our cumulative cellular phenotypes.
Copyright (C) 2019 by the American Association for the Advancement of Science
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Language: | English.
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Document Type: | Reviews.
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Journal Subset: | Life Sciences. Physical Science & Engineering.
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ISSN: | 0036-8075
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NLM Journal Code: | 0404511, uj7
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DOI Number: | https://dx.doi.org/10.1126/scien...- ouverture dans une nouvelle fenêtre
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