Information de reference pour ce titreAccession Number: | 00009772-201512000-00022.
|
Author: | Webster, Danielle L. MD, MS a, b, *; Fei, Lin PhD a; Falcone, Richard A. MD, MPH a, b; Kaplan, Jennifer M. MD, MS a, b
|
Institution: | (a) Cincinnati Children's Hospital Medical Center, Cincinnati, OH (b) University of Cincinnati College of Medicine, Cincinnati, OH
|
Title: | |
Source: | Journal of Critical Care. 30(6):1267-1271, December 2015.
|
Abstract: | Purpose: Hyperosmolar therapy is a mainstay in the acute medical management of traumatic brain injury (TBI). Emerging literature suggests that a hyperosmolar state may lead to thrombotic complications. The primary objective of this study was to investigate associations between hypertonic saline (HTS) and the outcome of deep venous thrombosis (DVT) in pediatric patients with severe TBI.
Materials and methods: This is a single-center retrospective cohort study of 58 patients admitted to the intensive care unit at a Level 1 pediatric trauma center between January 2010 and June 2013. Main measurements included volume of HTS administration, serum sodium levels, DVT confirmed with ultrasonography, survival at 30 days postinjury, and Glasgow Outcome Scale.
Results: The cumulative total bolus volume of HTS (mL/kg) given to each subject was associated with DVT (P = .01). Peak sodium level and 72-hour sustained sodium levels were associated with DVT (P = .05). A sustained sodium level of at least 160 mmol/L was associated with DVT (P = .02).
Conclusion: In children with severe TBI, the total bolus volume of 3% HTS and sustained sodium levels greater than 160 mmol/L are independently associated with DVT.
(C) 2015Elsevier, Inc.
|
Author Keywords: | TBI; Pediatrics; Hypertonic saline solution; Sodium; Venous thromboembolism.
|
References: | [1]. Anderson VA, Catroppa C, Haritou F, Morse S, Rosenfeld JV. Identifying factors contributing to child and family outcome 30 months after traumatic brain injury in children. J Neurol Neurosurg Psychiatry. 2005;76:401-408.
[2]. Kochanek PM, Carney N, Adelson PD, Ashwal S, Bell MJ, Bratton S, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents-second edition. Pediatr Crit Care Med. 2012;13(Suppl 1):S1-S82.
[3]. Huh JW, Raghupathi R. New concepts in treatment of pediatric traumatic brain injury. Anesthesiol Clin. 2009;27:213-240.
[4]. Morrow SE, Pearson M. Management strategies for severe closed head injuries in children. Semin Pediatr Surg. 2010;19:279-285.
[5]. Maxwell WL. Traumatic brain injury in the neonate, child and adolescent human: an overview of pathology. Int J Dev Neurosci. 2012;30:167-183.
[6]. Agbeko RS, Pearson S, Peters MJ, McNames J, Goldstein B. Intracranial pressure and cerebral perfusion pressure responses to head elevation changes in pediatric traumatic brain injury. Pediatr Crit Care Med. 2012;13:e39-e47.
[7]. Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 11. Use of hyperosmolar therapy in the management of severe pediatric traumatic brain injury. Pediatr Crit Care Med. 2003;4:S40-S44.
[8]. Fisher B, Thomas D, Peterson B. Hypertonic saline lowers raised intracranial pressure in children after head trauma. J Neurosurg Anesthesiol. 1992;4:4-10.
[9]. Peterson B, Khanna S, Fisher B, Marshall L. Prolonged hypernatremia controls elevated intracranial pressure in head-injured pediatric patients. Crit Care Med. 2000;28:1136-1143.
[10]. Simma B, Burger R, Falk M, Sacher P, Fanconi S. A prospective, randomized, and controlled study of fluid management in children with severe head injury: lactated Ringer's solution versus hypertonic saline. Crit Care Med. 1998;26:1265-1270.
[11]. Khanna S, Davis D, Peterson B, Fisher B, Tung H, O'Quigley J, et al. Use of hypertonic saline in the treatment of severe refractory posttraumatic intracranial hypertension in pediatric traumatic brain injury. Crit Care Med. 2000;28:1144-1151.
[12]. Worly JM, Fortenberry JD, Hansen I, Chambliss CR, Stockwell J. Deep venous thrombosis in children with diabetic ketoacidosis and femoral central venous catheters. Pediatrics. 2004;113:e57-e60.
[13]. Gutierrez JA, Bagatell R, Samson MP, Theodorou AA, Berg RA. Femoral central venous catheter-associated deep venous thrombosis in children with diabetic ketoacidosis. Crit Care Med. 2003;31:80-83.
[14]. Keenan CR, Murin S, White RH. High risk for venous thromboembolism in diabetics with hyperosmolar state: comparison with other acute medical illnesses. J Thromb Haemost. 2007;5:1185-1190.
[15]. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42:377-381.
[16]. Wakefield TW, McLafferty RB, Lohr JM, Caprini JA, Gillespie DL, Passman MA, et al. Call to action to prevent venous thromboembolism. J Vasc Surg. 2009;49:1620-1623.
[17]. Takemoto CM, Sohi S, Desai K, Bharaj R, Khanna A, McFarland S, et al. Hospital-associated venous thromboembolism in children: incidence and clinical characteristics. J Pediatr. 2014;164:332-338.
[18]. Setty BA, O'Brien SH, Kerlin BA. Pediatric venous thromboembolism in the United States: a tertiary care complication of chronic diseases. Pediatr Blood Cancer. 2012;59:258-264.
[19]. Candrilli SD, Balkrishnan R, O'Brien SH. Effect of injury severity on the incidence and utilization-related outcomes of venous thromboembolism in pediatric trauma inpatients. Pediatr Crit Care Med. 2009;10:554-557.
[20]. Raffini L, Huang YS, Witmer C, Feudtner C. Dramatic increase in venous thromboembolism in children's hospitals in the United States from 2001 to 2007. Pediatrics. 2009;124:1001-1008.
[21]. McCrory MC, Brady KM, Takemoto C, Tobias JD, Easley RB. Thrombotic disease in critically ill children. Pediatr Crit Care Med. 2011;12:80-89.
[22]. Monagle P, Chan AK, Goldenberg NA, Ichord RN, Journeycake JM, Nowak-Gottl U, et al. Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141:e737S-e801S.
[23]. Faustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, et al. Incidence and acute complications of asymptomatic central venous catheter-related deep venous thrombosis in critically ill children. J Pediatr. 2013;162:387-391.
[24]. Vidal E, Sharathkumar A, Glover J, Faustino EV. Central venous catheter-related thrombosis and thromboprophylaxis in children: a systematic review and meta-analysis. J Thromb Haemost. 2014;12:1096-1109.
[25]. Kanin M, Young G. Incidence of thrombosis in children with tunneled central venous access devices versus peripherally inserted central catheters (PICCs). Thromb Res. 2013;132:527-530.
[26]. Mannucci PM. Desmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years. Blood. 1997;90:2515-2521.
[27]. Grant PJ, Tate GM, Hughes JR, Davies JA, Prentice CR. Does hypernatraemia promote thrombosis? Thromb Res. 1985;40:393-399.
[28]. Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet. 1975;1:480-484.
[29]. Jennett B, Snoek J, Bond MR, Brooks N. Disability after severe head injury: observations on the use of the Glasgow Outcome Scale. J Neurol Neurosurg Psychiatry. 1981;44:285-293.
[30]. Beers SR, Wisniewski SR, Garcia-Filion P, Tian Y, Hahner T, Berger RP, et al. Validity of a pediatric version of the Glasgow Outcome Scale-Extended. J Neurotrauma. 2012;29:1126-1139.
|
Language: | English.
|
Document Type: | Neuro Critical Care.
|
Journal Subset: | Clinical Medicine.
|
ISSN: | 0883-9441
|
NLM Journal Code: | buy, 8610642
|
DOI Number: | https://dx.doi.org/10.1016/j.jcr...- ouverture dans une nouvelle fenêtre
|
Annotation(s) | |
|
|