Information de reference pour ce titreAccession Number: | 01445432-201412000-00011.
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Author: | Acheson, Ashley 1,2; Wijtenburg, Andrea S. 3; Rowland, Laura M. 3,4; Bray, Bethany C. 5; Gaston, Frank 3; Mathias, Charles W. 1; Fox, Peter T. 2; Lovallo, William R. 6; Wright, Susan N. 3; Hong, Elliot L. 3; McGuire, Stephen 7; Kochunov, Peter 3; Dougherty, Donald M. 1
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Institution: | (1) Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas, (2) Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, (3) Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, (4) Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, (5) The Methodology Center, The Pennsylvania State University, University Park, Pennsylvania, (6) Behavioral Sciences Laboratories, Veterans Affairs Medical Center and University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, (7) Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Texas,
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Title: | Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders.[Article]
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Source: | Human Brain Mapping. 35(12):5877-5887, December 2014.
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Abstract: | : Individuals with a family history of substance use disorder (FH+) show impaired frontal white matter as indicated by diffusion tensor imaging (DTI). This impairment may be due to impaired or delayed development of myelin in frontal regions, potentially contributing to this population's increased risk for developing substance use disorders. In this study, we examined high angular resolution DTI and proton magnetic resonance spectroscopy data from the anterior corona radiata were collected in 80 FH+ and 34 FH- youths (12.9 +/- 1.0 years old). White matter integrity indices included fractional anisotropy (FA), N-acetylaspartate (NAA), and total choline (tCho). Lower FA suggests decreased myelination. Decreased NAA coupled with higher tCho suggests impaired build-up and maintenance of cerebral myelin and consequently greater breakdown of cellular membranes. We found FH+ youths had lower FA (P < 0.0001) and NAA (P = 0.017) and higher tCho (P = 0.04). FH density (number of parents and grandparents with substance use disorders) was negatively correlated with FA (P < 0.0001) and NAA (P = 0.011) and positively correlated with tCho (P = 0.001). FA was independently predicted by both FH density (P =0.006) and NAA (P= 0.002), and NAA and tCho were both independent predictors of FH density (P < 0.001). Our finding of lower frontal FA in FH+ youths corresponding to lower NAA and increased tCho is consistent with delayed or impaired development of frontal white matter in FH+ youths. Longitudinal studies are needed to determine how these differences relate to substance use outcomes. Hum Brain Mapp 35:5877-5887, 2014. (C) 2014 Wiley Periodicals, Inc.
(C) 2014 John Wiley & Sons, Ltd
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Author Keywords: | frontal white matter integrity; family history; risk; diffusion tensor imaging; proton magnetic resonance spectroscopy; substance use.
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Language: | English.
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Document Type: | Research Articles.
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Journal Subset: | Life & Biomedical Sciences.
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ISSN: | 1065-9471
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DOI Number: | https://dx.doi.org/10.1002/hbm.2...- ouverture dans une nouvelle fenêtre
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