Information de reference pour ce titreAccession Number: | 01445492-900000000-99855.
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Author: | Takahashi, Yusuke 1; Tanaka, Maki 1; Murai, Ryosei 1; Kuribayashi, Kageaki 1; Kobayashi, Daisuke 1; Yanagihara, Nozomi 1; Watanabe, Naoki 1
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Institution: | (1) Department of Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
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Title: | |
Source: | Phytotherapy Research.
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Status: | Publish Ahead of Print, published online before print, 6 May 2014
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Abstract: | : Evidences are accumulating that extract of Acanthopanax senticosus Harms (ASH; syn Eleutherococcus senticosus [Rupr. & Maxim.] Maxim), a shrub native to Northeastern Asia, has antiinflammatory effects. In this study, we examined prophylactic and therapeutic effects of ASH extract (ASHE) on rheumatoid arthritis using collagen-induced arthritis (CIA) mouse model. Acanthopanax senticosus Harms extract was administered before the onset of arthritis in the prophylaxis model. In the therapeutic model, ASHE was administered after the onset of arthritis with or without anti-TNF-[alpha] antibody. The ASHE treatment showed efficacy before onset of CIA but there was no effect after CIA was established. The ASHE treatment delayed the onset and decreased severity of CIA. In vitro examinations showed that ASHE is an antioxidant and that ASHE suppresses TNF-[alpha] and interleukin-6 production in human peripheral blood mononuclear cells. The combination therapy with ASHE and anti-TNF-[alpha] antibody reduced the severity of arthritis compared with anti-TNF-[alpha] antibody alone. The present study shows that ASHE has prophylactic effect against CIA and support therapeutic effect of anti-TNF-[alpha] antibody. (C) 2014 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.
(C) 2024 John Wiley & Sons, Ltd
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Author Keywords: | Acanthopanax senticosus Harms; collagen-induced arthritis; reactive oxygen species; inflammatory cytokines; anti-TNF-[alpha] antibody.
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Language: | English.
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Document Type: | Research Articles: PDF Only.
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Journal Subset: | Pharmacology.
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ISSN: | 0951-418X
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DOI Number: | https://dx.doi.org/10.1002/ptr.5...- ouverture dans une nouvelle fenêtre
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