Information de reference pour ce titreAccession Number: | 01451459-201408150-00013.
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Author: | Andrews, Jason R. 1; Morrow, Carl 2; Walensky, Rochelle P. 1; Wood, Robin 2
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Institution: | (1)Division of Infectious Diseases, Massachusetts General Hospital, Boston (2)Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
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Title: | |
Source: | Journal of Infectious Diseases. 210(4):597-603, August 15, 2014.
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Abstract: | Background. Population models of tuberculosis transmission have not accounted for social contact structure and the role of the environment in which tuberculosis is transmitted.
Methods. We utilized extensions to the Wells-Riley model of tuberculosis transmission, using exhaled carbon dioxide as a tracer gas, to describe transmission patterns in an endemic community. Drawing upon social interaction data and carbon dioxide measurements from a South African township, we created an age-structured model of tuberculosis transmission in households, public transit, schools, and workplaces. We fit the model to local data on latent tuberculosis prevalence by age.
Results. Most tuberculosis infections (84%) were estimated to occur outside of one's own household. Fifty percent of infections among young adults (ages 15-19) occurred in schools, due to high contact rates and poor ventilation. Despite lower numbers of contacts in workplaces, assortative mixing among adults with high rates of smear-positive tuberculosis contributed to transmission in this environment. Households and public transit were important sites of transmission between age groups.
Conclusions. Consistent with molecular epidemiologic estimates, a minority of tuberculosis transmission was estimated to occur within households, which may limit the impact of contact investigations. Further work is needed to investigate the role of schools in tuberculosis transmission.
(C) Copyright Oxford University Press 2014.
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Author Keywords: | social contacts; tuberculosis; epidemiology; environment; mathematical models.
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Language: | English.
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Document Type: | MAJOR ARTICLES AND BRIEF REPORTS.
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ISSN: | 0022-1899
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DOI Number: | https://dx.doi.org/10.1093/infdi...- ouverture dans une nouvelle fenêtre
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