Information de reference pour ce titreAccession Number: | 00001756-201308070-00009.
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Author: | Cadenhead, Kristin S. a,b; Addington, Jean p; Cannon, Tyrone D. f; Cornblatt, Barbara A. h,i,j; de la Fuente-Sandoval, Camilo q; Mathalon, Dan H. c,d; Perkins, Diana O. k; Seidman, Larry J. l; Tsuang, Ming a; Walker, Elaine F. m; Woods, Scott W. g; Bachman, Peter e; Belger, Ayse k; Carrion, Ricardo E. h,i,j; Donkers, Franc C.L. k; Duncan, Erica o,n; Johannesen, Jason f; Leon-Ortiz, Pablo q; Light, Gregory a,b; Mondragon, Alejandra q; Niznikiewicz, Margaret l; Nunag, Jason a; Roach, Brian J. c,d; Solis-Vivanco, Rodolfo q; The North American Prodromal Longitudinal Studies Consortium
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Institution: | (a)Department of Psychiatry, University of California San Diego (UCSD) (b)Veteran's Affairs San Diego Healthcare System, La Jolla (c)Department of Psychiatry, University of California San Francisco (d)San Francisco VA Medical Center, San Francisco (e)Department of Psychology, University of California Los Angeles (UCLA), Los Angeles, California Departments of (f)Psychology (g)Psychiatry, Yale University, New Haven, Connecticut (h)Department of Psychiatry, The Zucker Hillside Hospital, New York (i)Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset (j)Department of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, New York (k)Department of Psychiatry, University of North Carolina (UNC), Chapel Hill, North Carolina (l)Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School Harvard, Boston, Massachusetts Departments of (m)Psychology (n)Psychiatry, Emory University (o)Atlanta Veteran's Affairs, Atlanta, Georgia, USA (p)Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada (q)Department of Psychiatry, National Institute of Neurology and Neurosurgery (INNN), Mexico City, Mexico
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Title: | |
Source: | Neuroreport. 24(11):626-630, August 7, 2013.
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Abstract: | Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI and startle reactivity exhibit substantial within-site stability; however, between-site stability has not been established. In two separate consortia investigating biomarkers of early psychosis, traveling participants studies were carried out as a part of quality assurance procedures to assess the fidelity of data across sites. In the North American Prodromal Longitudinal Studies (NAPLS) consortium, eight normal participants traveled to each of the eight NAPLS sites and were tested twice at each site on the startle PPI paradigm. In preparation for a binational study, 10 healthy participants were assessed twice in both San Diego and Mexico City. Intraclass correlations between and within sites were significant for PPI and startle response parameters, confirming the reliability of startle measures across sites in both consortia. There were between-site differences in startle magnitude in the NAPLS study that did not appear to be related to methods or equipment. In planning multisite studies, it is essential to institute quality assurance procedures early and establish between-site reliability to assure comparable data across sites.
(C) 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
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Author Keywords: | endophenotype; prepulse inhibition; reliability; startle.
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References: | 1. Braff DL.Prepulse inhibition of the startle reflex: a window on the brain in schizophrenia.Curr Top Behav Neurosci2010;4:349-371.
2. Graham FK.Presidential address, 1974. The more or less startling effects of weak prestimulation.Psychophysiology1975;12:238-248.
3. Braff DL, Grillon C, Geyer MA.Gating and habituation of the startle reflex in schizophrenic patients.Arch Gen Psychiatry1992;49:206-215.
4. Cadenhead KS, Carasso B, Swerdlow NR, Geyer MA, Braff DL.Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population.Biol Psychiatry1999;45:360-364.
5. Abel K, Waikar M, Pedro B, Hemsley D, Geyer M.Repeated testing of prepulse inhibition and habituation of the startle reflex: a study in healthy human controls.J Psychopharmacol1998;12:330-337.
6. Schwarzkopf SB, McCoy L, Smith DA, Boutros NN.Test-retest reliability of prepulse inhibition of the acoustic startle response.Biol Psychiatry1993;34:896-900.
7. Ludewig K, Geyer MA, Etzensberger M, Vollenweider FX.Stability of the acoustic startle reflex, prepulse inhibition, and habituation in schizophrenia.Schizophr Res2002;55:129-137.
8. Quednow BB, Kuhn KU, Beckmann K, Westheide J, Maier W, Wagner M.Attenuation of the prepulse inhibition of the acoustic startle response within and between sessions.Biol Psychol2006;71:256-263.
9. Flaten MA.Test-retest reliability of the somatosensory blink reflex and its inhibition.Int J Psychophysiol2002;45:261-265.
10. Light GA, Swerdlow NR, Rissling AJ, Radant A, Sugar CA, Sprock J, et al..Characterization of neurophysiologic and neurocognitive biomarkers for use in genomic and clinical outcome studies of schizophrenia.PLoS One2012;7:e39434.
11. Greenwood TA, Braff DL, Light GA, Cadenhead KS, Calkins ME, Dobie DJ, et al..Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia.Arch Gen Psychiatry2007;64:1242-1250.
12. Hasenkamp W, Epstein MP, Green A, Wilcox L, Boshoven W, Lewison B, Duncan E.Heritability of acoustic startle magnitude, prepulse inhibition, and startle latency in schizophrenia and control families.Psychiatry Res2010;178:236-243.
13. Greenwood TA, Lazzeroni LC, Murray SS, Cadenhead KS, Calkins ME, Dobie DJ, et al..Analysis of 94 Candidate Genes and 12 Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia.Am J Psychiatry2011;168:930-946.
14. Greenwood TA, Light GA, Swerdlow NR, Radant AD, Braff DL.Association analysis of 94 candidate genes and schizophrenia-related endophenotypes.PLoS One2012;7:e29630.
15. Gottesman II, Gould TD.The endophenotype concept in psychiatry: etymology and strategic intentions.Am J Psychiatry2003;160:636-645.
16. Cadenhead KS.Vulnerability markers in the schizophrenia spectrum: implications for phenomenology, genetics, and the identification of the schizophrenia prodrome.Psychiatr Clin North Am2002;25:837-853.
17. Miller TJ, McGlashan TH, Rosen JL, Cadenhead K, Cannon T, Ventura J, et al..Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability.Schizophr Bull2003;29:703-715.
18. Cannon TD, Cadenhead K, Cornblatt B, Woods SW, Addington J, Walker E, et al..Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America.Arch Gen Psychiatry2008;65:28-37.
19. Swerdlow NR, Sprock J, Light GA, Cadenhead K, Calkins ME, Dobie DJ, et al..Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia.Schizophr Res2007;92:237-251.
20. Cadenhead KS.Startle reactivity and prepulse inhibition in prodromal and early psychosis: effects of age, antipsychotics, tobacco and cannabis in a vulnerable population.Psychiatry Res2011;188:208-216.
21. Friedman L, Stern H, Brown GG, Mathalon DH, Turner J, Glover GH, et al..Test-retest and between-site reliability in a multicenter fMRI study.Hum Brain Mapp2008;29:958-972.
22. Brown GG, Mathalon DH, Stern H, Ford J, Mueller B, Greve DN, et al..Multisite reliability of cognitive BOLD data.Neuroimage2011;54:2163-2175.
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Language: | English.
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Document Type: | CLINICAL NEUROSCIENCE.
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Journal Subset: | Clinical Medicine. Behavioral & Social Sciences.
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ISSN: | 0959-4965
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NLM Journal Code: | a6m, 9100935
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DOI Number: | https://dx.doi.org/10.1097/WNR.0...- ouverture dans une nouvelle fenêtre
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