Information de reference pour ce titreAccession Number: | 00005768-201205000-00004.
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Author: | DUBE, JOHN J. 1; ALLISON, KATELYN F. 1; ROUSSON, VALENTIN 2; GOODPASTER, BRET H. 1; AMATI, FRANCESCA 1,3
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Institution: | (1)Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA; (2)Statistical Unit, Institute for Social and Preventive Medicine, University of Lausanne, Lausanne, SWITZERLAND; and (3)Department of Physiology and Service of Endocrinology, Diabetology and Metabolism, University of Lausanne, Lausanne, SWITZERLAND
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Title: | |
Source: | Medicine & Science in Sports & Exercise. 44(5):793-799, May 2012.
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Abstract: | Purpose: Exercise improves insulin resistance and is a first line for the prevention and treatment of type 2 diabetes. The extent, however, to which these responses are dose dependent is not known. The purpose of this study was to examine whether exercise dose was associated with improvements in insulin sensitivity after 4 months of exercise training in previously sedentary adults.
Methods: Fifty-five healthy volunteers participated in a 16-wk supervised endurance exercise intervention with a pre/postintervention design. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp, peak oxygen uptake by a graded exercise test, and body composition by dual-energy x-ray absorptiometry. The exercise intervention consisted of three to five sessions per week with a minimum of three sessions supervised. A ramped exercise prescription protocol was used to achieve 75% of peak HR for 45 min per session. Exercise dose, expressed as average kilocalories expended per week, was computed as the product of exercise intensity, duration and frequency.
Results: Improved insulin sensitivity was significantly related to exercise dose in a graded dose-response relationship. No evidence of threshold or maximal dose-response effect was observed. Age and gender did not influence this dose-response relationship. Exercise intensity was also significantly related to improvements in insulin sensitivity, whereas frequency was not.
Conclusions: This study identifies a graded dose-response relationship between exercise dose and improvements in insulin sensitivity. The implication of this observation is of importance for the adaptation of exercise prescription in clinical situations.
(C)2012The American College of Sports Medicine
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Author Keywords: | EXERCISE DOSE-RESPONSE; INSULIN RESISTANCE; OBESITY; TYPE 2 DIABETES; EXERCISE PRESCRIPTION.
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References: | 1. Ader M, Bergman RN. Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol. 1990; 258 (6 Pt 1): E1020-32.
2. Amati F, Dube JJ, Coen PM, Stefanovic-Racic M, Toledo FG, Goodpaster BH. Physical inactivity and obesity underlie the insulin resistance of aging. Diabetes Care. 2009; 32 (8): 1547-9.
3. Amati F, Dube JJ, Shay C, Goodpaster BH. Separate and combined effects of exercise training and weight loss on exercise efficiency and substrate oxidation. J Appl Physiol. 2008; 105 (3): 825-31.
4. Church TS, Blair SN. When will we treat physical activity as a legitimate medical therapy[horizontal ellipsis]even though it does not come in a pill? Br J Sports Med. 2009; 43 (2): 80-1.
5. Church TS, Earnest CP, Skinner JS, Blair SN. Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial. JAMA. 2007; 297 (19): 2081-91.
6. Coker RH, Hays NP, Williams RH, et al.. Exercise-induced changes in insulin action and glycogen metabolism in elderly adults. Med Sci Sports Exerc. 2006; 38 (3): 433-8.
7. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979; 237 (3): E214-23.
8. Dela F, Mikines KJ, von Linstow M, Secher NH, Galbo H. Effect of training on insulin-mediated glucose uptake in human muscle. Am J Physiol. 1992; 263 (6 Pt 1): E1134-43.
9. DiPietro L, Dziura J, Yeckel CW, Neufer PD. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol. 2006; 100 (1): 142-9.
10. Dube JJ, Amati F, Stefanovic-Racic M, Toledo FG, Sauers SE, Goodpaster BH. Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited. Am J Physiol Endocrinol Metab. 2008; 294 (5): E882-8.
11. Dube JJ, Amati F, Toledo FG, et al.. Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. Diabetologia. 2011; 54 (5): 1147-56.
12. Goodpaster BH, Katsiaras A, Kelley DE. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes. 2003; 52 (9): 2191-7.
13. Hawley JA, Lessard SJ. Exercise training-induced improvements in insulin action. Acta Physiol (Oxf). 2008; 192 (1): 127-35.
14. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med. 1991; 325 (3): 147-52.
15. Holloszy JO. Exercise-induced increase in muscle insulin sensitivity. J Appl Physiol. 2005; 99 (1): 338-43.
16. Houmard JA, Tanner CJ, Slentz CA, Duscha BD, McCartney JS, Kraus WE. Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol. 2004; 96 (1): 101-6.
17. Hu FB, Sigal RJ, Rich-Edwards JW, et al.. Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. JAMA. 1999; 282 (15): 1433-9.
18. Hughes VA, Fiatarone MA, Fielding RA, et al.. Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol. 1993; 264 (6 Pt 1): E855-62.
19. Kelley DE, Goodpaster BH. Effects of exercise on glucose homeostasis in type 2 diabetes mellitus. Med Sci Sports Exerc. 2001; 33 (Suppl 6): S495-S501; discussion S28-9.
20. Kesaniemi YK, Danforth E, Jensen MD, Kopelman PG, Lefebvre P, Reeder BA. Dose-response issues concerning physical activity and health: an evidence-based symposium. Med Sci Sports Exerc. 2001; 33 (Suppl 6): S351-8.
21. Kirwan JP, Solomon TP, Wojta DM, Staten MA, Holloszy JO. Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab. 2009; 297 (1): E151-6.
22. Lee D-C, Sui X, Church TS, Lee I-M, Blair SN. Associations of cardiorespiratory fitness and obesity with risks of impaired fasting glucose and type 2 diabetes in men. Diabetes Care. 2009; 32 (2): 257-62.
23. Magkos F, Tsekouras Y, Kavouras SA, Mittendorfer B, Sidossis LS. Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure. Clin Sci. 2008; 114 (1): 59-64.
24. Mayer-Davis EJ, D'Agostino R Jr, Karter AJ, et al.. Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. JAMA. 1998; 279 (9): 669-74.
25. Mikines KJ, Sonne B, Farrell PA, Tronier B, Galbo H. Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am J Physiol. 1988; 254 (3 Pt 1): E248-59.
26. Mikines KJ, Sonne B, Farrell PA, Tronier B, Galbo H. Effect of training on the dose-response relationship for insulin action in men. J Appl Physiol. 1989; 66 (2): 695-703.
27. NIH Consensus Development Panel on Physical Activity and Cardiovascular Health, and NIH. Physical activity and cardiovascular health. JAMA. 1996; 276 (3): 241-6.
28. Oshida Y, Yamanouchi K, Hayamizu S, Sato Y. Long-term mild jogging increases insulin action despite no influence on body mass index or V[spacing dot above]O2max. J Appl Physiol. 1989; 66 (5): 2206-10.
29. Pruchnic R, Katsiaras A, He J, Kelley DE, Winters C, Goodpaster BH. Exercise training increases intramyocellular lipid and oxidative capacity in older adults. Am J Physiol Endocrinol Metab. 2004; 287 (5): E857-62.
30. Seals DR, Hagberg JM, Hurley BF, Ehsani AA, Holloszy JO. Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women. JAMA. 1984; 252 (5): 645-9.
31. Short KR, Vittone JL, Bigelow ML, et al.. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes. 2003; 52 (8): 1888-96.
32. Sieverdes JC, Sui X, Lee D-C, et al.. Physical activity, cardiorespiratory fitness and the incidence of type 2 diabetes in a prospective study of men. Br J Sports Med. 2010; 44 (4): 238-44.
33. Sui X, Hooker SP, Lee I-M, et al.. A prospective study of cardiorespiratory fitness and risk of type 2 diabetes in women. Diabetes Care. 2008; 31 (3): 550-5.
34. US Department of Health and Human Services PAGAC. Physical Activity Guidelines Advisory Committee Report [Internet]. 2008 [cited 2011 Oct 10]. Available from: http://www.health.gov/PAguidelin...- ouverture dans une nouvelle fenêtre.
35. Zierath JR. Invited review: exercise training-induced changes in insulin signaling in skeletal muscle. J Appl Physiol. 2002; 93 (2): 773-81.
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Language: | English.
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Document Type: | CLINICAL SCIENCES.
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Journal Subset: | Clinical Medicine. Health Professions.
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ISSN: | 0195-9131
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NLM Journal Code: | 8005433, mg8
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DOI Number: | https://dx.doi.org/10.1249/MSS.0...- ouverture dans une nouvelle fenêtre
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