Information de reference pour ce titreAccession Number: | 00003458-201110000-00027.
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Author: | Rowan, Janet A. MBCHB 1,; Rush, Elaine C. PHD 2; Obolonkin, Victor BSC 3; Battin, Malcolm MD 4; Wouldes, Trecia PHD 5; Hague, William M. MD 6
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Institution: | (1)Department of Obstetrics, National Women's Health, Auckland, New Zealand (2)Centre for Child Health Research, Auckland University of Technology, Auckland, New Zealand (3)Department of Biological Sciences, University of Auckland, Auckland, New Zealand (4)Department of Pediatrics, National Women's Health, Auckland, New Zealand (5)Department of Psychological Medicine, University of Auckland, Auckland, New Zealand (6)Department of Obstetrics, Women and Children's Hospital, University of Adelaide, Adelaide, Australia
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Title: | Metformin in Gestational Diabetes: The Offspring Follow-Up (MiG TOFU): Body composition at 2 years of age.[Article]
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Source: | Diabetes Care. 34(10):2279-2284, October 2011.
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Abstract: | OBJECTIVE: In women with gestational diabetes mellitus, who were randomized to metformin or insulin treatment, pregnancy outcomes were similar (Metformin in Gestational diabetes [MiG] trial). Metformin crosses the placenta, so it is important to assess potential effects on growth of the children.
RESEARCH DESIGN AND METHODS: In Auckland, New Zealand, and Adelaide, Australia, women who had participated in the MiG trial were reviewed when their children were 2 years old. Body composition was measured in 154 and 164 children whose mothers had been randomized to metformin and insulin, respectively. Children were assessed with anthropometry, bioimpedance, and dual energy X-ray absorptiometry (DEXA), using standard methods.
RESULTS: The children were similar for baseline maternal characteristics and pregnancy outcomes. In the metformin group, compared with the insulin group, children had larger mid-upper arm circumferences (17.2 +/- 1.5 vs. 16.7 +/- 1.5 cm; P = 0.002) and subscapular (6.3 +/- 1.9 vs. 6.0 +/- 1.7 mm; P = 0.02) and biceps skinfolds (6.03 +/- 1.9 vs. 5.6 +/- 1.7 mm; P = 0.04). Total fat mass and percentage body fat assessed by bioimpedance (n = 221) and DEXA (n = 114) were not different.
CONCLUSIONS: Children exposed to metformin had larger measures of subcutaneous fat, but overall body fat was the same as in children whose mothers were treated with insulin alone. Further follow-up is required to examine whether these findings persist into later life and whether children exposed to metformin will develop less visceral fat and be more insulin sensitive. If so, this would have significant implications for the current pandemic of diabetes.
(C) 2011 by the American Diabetes Association, Inc.
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Language: | English.
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Document Type: | Original Research.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0149-5992
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NLM Journal Code: | eag, 7805975
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DOI Number: | https://dx.doi.org/10.2337/dc11-...- ouverture dans une nouvelle fenêtre
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