Information de reference pour ce titreAccession Number: | 01451459-201109150-00020.
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Author: | Nduati, Eunice 1; Gwela, Agnes 1,a; Karanja, Henry 1; Mugyenyi, Cleopatra 1; Langhorne, Jean 2; Marsh, Kevin 1,3; Urban, Britta C. 1,4
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Institution: | (1)KEMRI/Wellcome Trust Collaborative Research Program, Centre for Geographical Medicine Research, Kilifi, Kenya (2)Division of Parasitology, MRC, National Institute for Medical Research, London (3)Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington (4)Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, United Kingdom
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Title: | |
Source: | Journal of Infectious Diseases. 204(6):962-970, September 15, 2011.
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Abstract: | Malaria-specific antibody responses in children often appear to be short-lived but the mechanisms underlying this phenomenon are not well understood. In this study, we investigated the relationship between the B-cell activating factor (BAFF) and its receptors expressed on B cells with antibody responses during and after acute malaria in children. Our results demonstrate that BAFF plasma levels increased during acute malarial disease and reflected disease severity. The expression profiles for BAFF receptors on B cells agreed with rapid activation and differentiation of a proportion of B cells to plasma cells. However, BAFF receptor (BAFF-R) expression was reduced on all peripheral blood B cells during acute infection, but those children with the highest level of BAFF-R expression on B cells maintained schizont-specific immunoglobin G (IgG) over a period of 4 months, indicating that dysregulation of BAFF-R expression on B cells may contribute to short-lived antibody responses to malarial antigens in children. In summary, this study suggests a potential role for BAFF during malaria disease, both as a marker for disease severity and in shaping the differentiation pattern of antigen-specific B cells.
(C) Copyright Oxford University Press 2011.
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Language: | English.
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Document Type: | MAJOR ARTICLES AND BRIEF REPORTS.
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ISSN: | 0022-1899
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DOI Number: | https://dx.doi.org/10.1093/infdi...- ouverture dans une nouvelle fenêtre
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