Information de reference pour ce titreAccession Number: | 00008563-201111010-00021.
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Author: | Garcia-Closas, Montserrat 1,2,*,+; Ye, Yuanqing 3,+; Rothman, Nathaniel 1,+; Figueroa, Jonine D. 1,+; Malats, Nuria 4,+; Dinney, Colin P. 5,+; Chatterjee, Nilanjan 1,+; Prokunina-Olsson, Ludmila 1,+; Wang, Zhaoming 6,+; Lin, Jie 3,+; Real, Francisco X. 4,7; Jacobs, Kevin B. 6; Baris, Dalsu 1; Thun, Michael 8; De Vivo, Immaculata 9; Albanes, Demetrius 1; Purdue, Mark P. 1; Kogevinas, Manolis 10,11,12,13; Kamat, Ashish M. 5; Lerner, Seth P. 14; Barton Grossman, H. 5; Gu, Jian 3; Pu, Xia 3; Hutchinson, Amy 6; Fu, Yi-Ping 1; Burdett, Laurie 6; Yeager, Meredith 6; Tang, Wei 1; Tardon, Adonina 12,15; Serra, Consol 7; Carrato, Alfredo 16; Garcia-Closas, Reina 17; Lloreta, Josep 7,11; Johnson, Alison 18; Schwenn, Molly 19; Karagas, Margaret R. 20; Schned, Alan 22; Andriole, Gerald Jr 21; Grubb, Robert III 21; Black, Amanda 1; Jacobs, Eric J. 8; Ryan Diver, W. 8; Gapstur, Susan M. 8; Weinstein, Stephanie J. 1; Virtamo, Jarmo 22; Hunter, David J. 23; Caporaso, Neil 1; Teresa Landi, Maria 1; Fraumeni, Joseph F. Jr 1; Silverman, Debra T. 1,+; Chanock, Stephen J. 1,+; Wu, Xifeng 3,+
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Institution: | (1)Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, (2)Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK, (3)Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, (4)Spanish National Cancer Research Centre, Madrid, Spain, (5)Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, (6)Core Genotype Facility, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD, USA, (7)Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain, (8)Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA, (9)Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA, (10)Centre de Recerca en Epidemiologia Ambiental (CREAL), Barcelona, Spain, (11)Parc de Salut Mar -Institut Municipal d'Investigacio' Medica (IMIM), Barcelona, Spain, (12)CIBER de Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain, (13)National School of Public Health, Athens, Greece, (14)Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA, (15)Universidad de Oviedo, Oviedo, Spain, (16)Ramon y Cajal University Hospital, Madrid, Spain, (17)Unidad de Investigacion, Hospital Universitario de Canarias, La Laguna, Spain, (18)Vermont Cancer Registry, Burlington, VT, USA, (19)Maine Cancer Registry, Augusta, ME, USA, (20)Dartmouth Medical School, Hanover, NH, USA, (21)Department of Urology, Washington University School of Medicine, St Louis, MO, USA, (22)National Institute for Health and Welfare, Helsinki, Finland and (23)Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA
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Title: | |
Source: | Human Molecular Genetics. 20(21):4282-4289, November 1, 2011.
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Abstract: | Genome-wide and candidate-gene association studies of bladder cancer have identified 10 susceptibility loci thus far. We conducted a meta-analysis of two previously published genome-wide scans (4501 cases and 6076 controls of European background) and followed up the most significant association signals [17 single nucleotide polymorphisms (SNPs) in 10 genomic regions] in 1382 cases and 2201 controls from four studies. A combined analysis adjusted for study center, age, sex, and smoking status identified a novel susceptibility locus that mapped to a region of 18q12.3, marked by rs7238033 (P = 8.7 x 10-9; allelic odds ratio 1.20 with 95% CI: 1.13-1.28) and two highly correlated SNPs, rs10775480/rs10853535 (r2= 1.00; P = 8.9 x 10-9; allelic odds ratio 1.16 with 95% CI: 1.10-1.22). The signal localizes to the solute carrier family 14 member 1 gene, SLC14A1, a urea transporter that regulates cellular osmotic pressure. In the kidney, SLC14A1 regulates urine volume and concentration whereas in erythrocytes it determines the Kidd blood groups. Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis.
(C) Copyright Oxford University Press 2011.
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Language: | English.
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Document Type: | ASSOCIATION STUDIES ARTICLES.
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Journal Subset: | Life & Biomedical Sciences.
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ISSN: | 0964-6906
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NLM Journal Code: | brc, 9208958
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DOI Number: | https://dx.doi.org/10.1093/hmg/d...- ouverture dans une nouvelle fenêtre
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