Information de reference pour ce titreAccession Number: | 00002792-201103080-00008.
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Author: | Eisenberg, Mark J. MD MPH; Afilalo, Jonathan MD MSc; Lawler, Patrick R. MD; Abrahamowicz, Michal PhD; Richard, Hugues MSc; Pilote, Louise MD MPH PhD
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Institution: | From the Divisions of Cardiology and Clinical Epidemiology (Eisenberg, Afilalo), Jewish General Hospital, Montreal, Que.; the Faculty of Medicine (Eisenberg, Afilalo, Lawler, Pilote) and the Department of Epidemiology, Biostatistics and Occupational Health (Eisenberg, Abrahamowicz, Pilote), McGill University, Montreal, Que.; and the Division of Clinical Epidemiology (Abrahamowicz, Richard, Pilote) and the Division of Internal Medicine, Department of Medicine (Pilote), McGill University Health Centre, Montreal, Que
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Title: | Cancer risk related to low-dose ionizing radiation from cardiac imaging in patients after acute myocardial infarction.[Miscellaneous Article]
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Source: | CMAJ Canadian Medical Association Journal. 183(4):430-436, March 8, 2011.
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Abstract: | Background: Patients exposed to low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction may be at increased risk of cancer.
Methods: Using an administrative database, we selected a cohort of patients who had an acute myocardial infarction between April 1996 and March 2006 and no history of cancer. We documented all cardiac imaging and therapeutic procedures involving low-dose ionizing radiation. The primary outcome was risk of cancer. Statistical analyses were performed using a time-dependent Cox model adjusted for age, sex and exposure to low-dose ionizing radiation from noncardiac imaging to account for work-up of cancer.
Results: Of the 82 861 patients included in the cohort, 77% underwent at least one cardiac imaging or therapeutic procedure involving low-dose ionizing radiation in the first year after acute myocardial infarction. The cumulative exposure to radiation from cardiac procedures was 5.3 milliSieverts (mSv) per patient-year, of which 84% occurred during the first year after acute myocardial infarction. A total of 12 020 incident cancers were diagnosed during the follow-up period. There was a dose-dependent relation between exposure to radiation from cardiac procedures and subsequent risk of cancer. For every 10 mSv of low-dose ionizing radiation, there was a 3% increase in the risk of age- and sex-adjusted cancer over a mean follow-up period of five years (hazard ratio 1.003 per milliSievert, 95% confidence interval 1.002-1.004).
Interpretation: Exposure to low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction is associated with an increased risk of cancer.
(C) 2011 Canadian Medical Association; Association medicale canadienne
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Language: | English.
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Document Type: | Research.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0820-3946
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NLM Journal Code: | 9711805
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DOI Number: | https://dx.doi.org/10.1503/cmaj....- ouverture dans une nouvelle fenêtre
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