Information de reference pour ce titreAccession Number: | 00043605-201012000-00025.
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Author: | Desrumaux, Catherine; Deckert, Valerie; Lemaire-Ewing, Stephanie; Mossiat, Claude; Athias, Anne; Vandroux, David; Dumont, Laure; Monier, Serge; Pais de Barros, Jean-Paul; Klein, Alexis; De Maistre, Emmanuel; Blache, Denis; Beley, Alain; Marie, Christine; Garnier, Philippe; Lagrost, Laurent
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Institution: | From the Institut National de la Sante et de la Recherche Medicale (INSERM) UMR866, Dijon, France (C.D., V.D., S.L.-E., A.A., S.M., J.-P.P.d.B., A.K., D.B., L.L.); Universite de Bourgogne, Dijon, France (C.D., V.D., S.L.-E., C. Mossiat, A.A., D.V., L.D., S.M., J.-P.P.d.B., A.K., D.B., E.D.M., A.B., C. Marie, P.G., L.L.); CHU, Hopital du Bocage, Dijon, France (S.L.-E., D.V., L.D., E.D.M., L.L.); INSERM U887, Dijon, France (C. Mossiat, A.B., C. Marie, P.G.). Current affiliation of Dr Desrumaux: INSERM U710-EPHE, Universite Montpellier 2, Montpellier, France.
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Title: | |
Source: | Arteriosclerosis, Thrombosis & Vascular Biology. 30(12):2452-2457, December 2010.
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Abstract: | Objective-: Earlier in vitro studies suggested a putative role for the plasma phospholipid transfer protein (PLTP) in the modulation of blood coagulation. The effect of PLTP expression on blood coagulation under both basal and oxidative stress conditions was compared here in wild-type and PLTP-deficient (PLTP-/-) mice.
Methods and Results-: Under basal conditions, PLTP deficiency was associated with an extended tail bleeding time despite a significant depletion of vascular [alpha]-tocopherol content and an impairment of endothelial function. When acute oxidative stress was generated in vivo in the brain vasculature, the steady state levels of oxidized lipid derivatives, the extent of blood vessel occlusion, and the volume of ischemic lesions were more severe in wild-type than in PLTP-/- mice.
Conclusion-: In addition to its recognized hyperlipidemic, proinflammatory, and proatherogenic properties, PLTP increases blood coagulation and worsens the extent of ischemic lesions in response to acute oxidative stress. Thus, PLTP arises here as a cardiovascular risk factor for the late thrombotic events occurring in the acute phase of atherosclerosis.
(C) 2010 American Heart Association, Inc.
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Author Keywords: | blood coagulation; endothelial function; lipids; thrombosis; vascular biology.
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Language: | English.
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Document Type: | Integrative Physiology/Experimental Medicine: Vascular Biology.
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Journal Subset: | Clinical Medicine.
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ISSN: | 1079-5642
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NLM Journal Code: | 9505803, B89
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DOI Number: | https://dx.doi.org/10.1161/ATVBA...- ouverture dans une nouvelle fenêtre
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