Information de reference pour ce titreAccession Number: | 01445509-201105000-00004.
|
Author: | Lopez, Ester M. 1; Tagliaferro, Patricia 1; Onaivi, Emmanuel S. 2; Lopez-Costa, Juan J. 1,*
|
Institution: | (1)Instituto de Biologia Celular y Neurociencia "Prof. E. De Robertis," Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina (2)Department of Biology, William Patterson University, Wayne, New Jersey 07470
|
Title: | |
Source: | Synapse. 65(5):388-392, May 2011.
|
Abstract: | : Cannabinoid effects are mediated through two receptors, CB1 and CB2. In the retina CB1 has been reported in bipolar cells, gabaergic amacrine cells, horizontal cells, and inner plexiform layer. CB2 receptor mRNA localization was shown in photoreceptors, inner nuclear layer, and ganglion cell layer by using RT-PCR. The aim of this work was to localize CB2 receptor in the rat retina by using immunocytochemistry. Our results showed that CB2 receptor was localized in retinal pigmentary epithelium, inner photoreceptor segments, horizontal and amacrine cells, cells localized in ganglion cell layer, and in fibers of inner plexiform layer. These results are in agreement with studies using RT-PCR and provide some additional information about the distribution of CB2 receptor. Further studies are needed to clarify the role of this cannabinoid receptor in the retina. Synapse, 2010. (C) 2010 Wiley-Liss, Inc.
Copyright (C) 2011 John Wiley & Sons, Inc.
|
Author Keywords: | CB2; cannabinoid receptor; rat; retina.
|
References: | Abbler AS, Chang CJ, Full J, Tso MO, Lam TT. 1996. Photic injury triggers apoptosis of photoreceptor cells. Res Commun Mol Pathol Pharmacol 92:177-189.
Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP. 2003. Age-related macular degeneration: Etiology, pathogenesis and therapeutic strategies. Surv Ophthalmol 48:257-293.
Ashtron JC, Friberg D, Darlington CL, Smith PF. 2006. Expression of the cannabinoid CB2 receptor in rat cerebellum: An inmunocitochemical study. Neurosci Lett 396:113-116.
Bressler SB. 2009. Introduction: Understanding the role of angiogenesis and antiangiogenic agents in age-related macular regeneration. Ophthalmology 116:S1-S7.
Brusco A, Tagliaferro P, Saez T, Onaivi ES. 2008. Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Synapse 62:944-949.
Compton DR, Gold LH, Ward SJ, Balser RL, Martin BR. 1992. Aminoalkylindole analogs: Cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol. J Pharmacol Exp Ther 263:1118-1126.
Connolly SE, Hjelmeland LM, La Vail MM. 1992. Immunohistochemical localization of basic fibroblast growth factor in mature and developing retinas of normal and RCS rats. Curr Eye Res 11:1005-1017.
El-Remessy AB, Khalil IE, Matragoon S, Abou-Mohamed G, Tsai NJ, Roon P, Caldwell RB, Caldwell RW, Green K, Liou GI. 2003. Neuroprotective effect of (-) delta 9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity involvement of peroxynitrite. Am J Pathol 163:1997-2008.
Galve-Roperh I, Aguado T, Palazuelos J, Guzman M. 2008. Mechanisms of control of neuron survival by endocannabinoid system. Curr Pharm Des 14:2279-2288.
Gao H, Hollyfield JG. 1992. Basic fibroblast growth factor (bFGF) immunolicalization in the rodent outer retina demonstrated with an anti-rodent bFGF antibody. Brain Res 585:355-360.
Gong JP, Onaivi ES, Ishiguro H, Liu QR, Tagliaferro PA, Brusco A, Uhl GR. 2006. Cannabinoid CB2 receptors: Immunocytochemical localization in rat brain. Brain Res 1071:10-23.
Grant I, Cahn BR. 2005. Cannabis and endocannabinoid modulators: Therapeutic promises and challenges. Clin Neurosci Res 5:185-199.
Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC. 1991. Characterization and localization of cannabinoid receptor in rat brain: A quantitative in vitro autorradiografic study. J Neurosci 11:563-583.
Hosseini A, Lattanzio FA, Williams PB, Tibbs D, Samudre SS, Allen RC. 2006. Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects. Exp Eye Res 82:753-759.
Lu Q, Straiker A, Lu Q, Maguire G. 2000. Expresion of CB2 cannabinoid receptor mRNA in adult rat retina. Vis Neurosci 17:91-95.
Lutz B. 2002. Molecular biology of cannabinoid receptos. Prostaglandins Leukot Essent Fatty Acids 66:123-142.
Matias I, Wang JW, Moriello AS, Nieves A, Woodward DF, Di Marzo V. 2006. Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. Prostaglandins Leukot Essent Fatty Acids 75:413-418.
Matsuda LA, Bonner TI, Lolait SJ. 1993. Localization of cannabinoid receptor mRNA in rat Brain. J Comp Neurology 327:535-550.
Nucci C, Gasperi V, Tartaglione R, Cerulli A, Terrinoni A, Bari M, De Simone C, Agro AF, Morrone LA, Corasaniti MT, Bagetta G, Maccarrone N. 2007. Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats. Invest Ophthalmol Vis Sci 48:2997-3004.
Onaivi E, Ishiguro I, Gong J, Patel S, Perchuk A, Meozzi PA, Myers L, Mora Z, Tagliaferro P, Gardner E, Brusco A, Akinshola BE, Liu Q-R, Hope B, Iwasaki S, Arinami T, Teasenfitz L, Uhl G. 2006. Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann NY Acad Sci 1074:514-536.
Park CM, Hollenberg MJ. 1989. Basic fibroblast growth factor induces retinal regeneration in vivo. Dev Biol 134:201-205.
Park CM, Hollenberg MJ. 1991. Induction of retinal regeneration in vivo by growth factors. Dev Biol 148:322-333.
Pertwee RG. 2008. Ligands that target cannabinoid receptors in the brain: From THC to anandamide and beyond. Addict Biol 13:147-159.
Saint-Geniez M, Kurihara T, Sekiyama E, Maldonado AE, D'Amore PA. 2009. An essential role for RPE-derived soluble VEGF in the maintenance of choriocapilaris. Proc Natl Acad Sci 106:18751-18756.
Straiker AJ, Maguire G, Mackie K, Linsey J. 1999. Localization of cannabinoid CB1 receptors in the human anterior eye and retina. Invest Ophthalmol Vis Sci 40:2442-2448.
Suarez J, Bermudez-Silva FJ, Mackie K, Ledent C, Zimmer A, Cravant BF, de Fonseca FR. 2008. Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functional related nuclei. J Comp Neurol 509:400-421.
Svizenska I, Dubovy P, Sulcova A. 2008. Cannabinoid receptors 1 and 2 (CB1 and CB2) their distribution, ligands and functional involvement in nervous system structures-A short review. Pharmacol Biochem Behav 90:501-511.
Thakur GA, Tichkule R, Bajaj S, Makriyannis A. 2009. Latest advances in cannabinoid receptor agonists. Expert Opin Ther Pat 19:1647-1673.
Tsou K, Brown S, Sanudi-Pena MC, Mackie K, Walker JM. 1998. Immunocytochemical distribution of cannabinoid CB1 receptors in the rat nervous system. Neuroscience 83:393-411.
Van Sikle MD, Ducan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N, Makriyannis A, Piomelli D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD, Sharkey KA. 2005. Identification and functional characterization of brainstem cannabinoid CB2 receptor. Science 310:329-332.
Ward SJ, Baizman E, Bell M, Childers S, D'Ambra T, Eissenstat M, Estep K, Haycock D, Howlett A, Luttinger D. 1991. Aminoakylindoles (AAIs): A new route to cannabinois receptor? NIDA Res Monogr 105:425-426.
Wilson RI, Nicoll RA. 2001. Endogenous cannabinoids mediate retrograde signaling at hippocampal synapses. Nature 410:588-592.
Wilson RI, Nicoll RA. 2002. Endocannabinoid signaling in the brain. Science 296:678-682.
Yan Wei, Xu Wan, Ling Wang. 2009. Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells. Mol Vision 15:1243-1251.
Yazulla S. 2008. Enndocannabinois in the retina: From marijuana to neuroprotection. Prog Retin Eye Res 27:501-526.
Yazulla S, Studholme KM, Mc Intosh HH, Deutsch DG. 1999. Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina. J Comp Neurol 415:80-90.
Zhong L, Geng L, Njie Y, Feng W, Song ZH. 2005. CB2 cannabinoid receptors in trabecular meshwork cells mediate JW015-induced enhancement of aqueous humor outflow facility. Invest Opthamol Vis Sci 46:1988-1992.
|
Language: | English.
|
Document Type: | Research Articles.
|
Journal Subset: | Life & Biomedical Sciences.
|
ISSN: | 0887-4476
|
DOI Number: | https://dx.doi.org/10.1002/syn.2...- ouverture dans une nouvelle fenêtre
|
Annotation(s) | |
|
|