Information de reference pour ce titreAccession Number: | 00006056-201003040-00046.
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Author: | Hittinger, Chris Todd 1,2; Goncalves, Paula 3; Sampaio, Jose Paulo 3; Dover, Jim 1,2; Johnston, Mark 1,2; Rokas, Antonis 4
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Institution: | (1)Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA (2)Center for Genome Sciences, Department of Genetics, Washington University in St Louis, School of Medicine, St Louis, Missouri 63108, USA (3)Centro de Recursos Microbiologicos, Departamento de Ciencias da Vida, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal (4)Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
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Title: | Remarkably ancient balanced polymorphisms in a multi-locus gene network.[Article]
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Source: | Nature. 464(7285):54-58, March 4, 2010.
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Abstract: | : Local adaptations within species are often governed by several interacting genes scattered throughout the genome. Single-locus models of selection cannot explain the maintenance of such complex variation because recombination separates co-adapted alleles. Here we report a previously unrecognized type of intraspecific multi-locus genetic variation that has been maintained over a vast period. The galactose (GAL) utilization gene network of Saccharomyces kudriavzevii, a relative of brewer's yeast, exists in two distinct states: a functional gene network in Portuguese strains and, in Japanese strains, a non-functional gene network of allelic pseudogenes. Genome sequencing of all available S. kudriavzevii strains revealed that none of the functional GAL genes were acquired from other species. Rather, these polymorphisms have been maintained for nearly the entire history of the species, despite more recent gene flow genome-wide. Experimental evidence suggests that inactivation of the GAL3 and GAL80 regulatory genes facilitated the origin and long-term maintenance of the two gene network states. This striking example of a balanced unlinked gene network polymorphism introduces a remarkable type of intraspecific variation that may be widespread.
(C) 2010 Nature Publishing Group
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Language: | English.
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Document Type: | ARTICLES.
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Journal Subset: | Life Sciences. Physical Science & Engineering.
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ISSN: | 0028-0836
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NLM Journal Code: | 0410462, nsc
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DOI Number: | https://dx.doi.org/10.1038/natur...- ouverture dans une nouvelle fenêtre
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