Information de reference pour ce titreAccession Number: | 00134502-200901000-00003.
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Author: | Hogman, Marieann 1,2,3; Lafih, Jaroslava 1; Merilainen, Pekka 4; Broms, Kristina 1; Malinovschi, Andrei 2,3; Janson, Christer 3,5
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Institution: | (1)Centre for Research and Development, Uppsala University/CountyCouncil of Gavleborg, Gavle, Sweden, (2)Department of Medical Cell Biology; Integrative Physiology, Uppsala University, Uppsala, Sweden, (3)Asthma and Allergy Research Centre, Uppsala University, Uppsala, Sweden, (4)Laboratory of Biomedical Engineering, Helsinki University of Technology, Helsinki, Finland, and (5)Department of Medical Sciences, Respiratory Medicine & Allergology, Uppsala University, Uppsala, Sweden
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Title: | |
Source: | Clinical Physiology & Functional Imaging. 29(1):18-23, January 2009.
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Abstract: | Introduction: There is an interest in modelling exhaled nitric oxide (NO). Studies have shown that flow-independent NO parameters i.e. NO of the alveolar region (CANO), airway wall (CawNO), diffusing capacity (DawNO) and flux (JawNO), are altered in several disease states such as asthma, cystic fibrosis, alveolitis and chronic obsmuctive pulmonary disease (COPD). However, values from a healthy population are missing.
Objectives: To calculate NO parameters in a healthy population by collecting NO values at different exhalation flow rates.
Methods: A random sample from the ECRHS II study was investigated. Among the 281 subjects that had performed a bronchial hyperreactivity (BHR)-test, FEV1[middle dot]0, IgE and NO-analyses 89 were found to be healthy.
Results: There were no differences in FENO0[middle dot]05 or NO parameters between men and women. There were weak correlations between height and both FENO0[middle dot]05 (r = 0[middle dot]23, P = 0[middle dot]03) and CawNO (r = 0[middle dot]22, P = 0[middle dot]04). There was also a correlation between age and CANO (r = 0[middle dot]28, P = 0[middle dot]007). When controlled for gender, this correlation was more powerful in women (r = 0[middle dot]51, P = 0[middle dot]001) but did not remain for male subjects.
Conclusion: Extended NO analysis is a simple non-invasive tool that gives by far more information than FENO0[middle dot]05. Based on our results, we suggest that the values for healthy subjects should be considered to fall between the following ranges: FENO0[middle dot]05, 10-30 ppb; CawNO, 50-250 ppb; DawNO, 5-15 ml s-1; JawNO, 0[middle dot]8-1[middle dot]6 nl s-1; and CANO, 0-4 ppb. Values outside these intervals indicate the need for further investigation to exclude a state of disease.
Copyright (C) 2009 Blackwell Publishing Ltd.
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Author Keywords: | adults; exhaled nitric oxide; extended nitric oxide analysis; flow rate; gender; health; humans.
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Language: | English.
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Document Type: | Original Article.
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Journal Subset: | Clinical Medicine. Life Sciences.
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ISSN: | 1475-0961
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NLM Journal Code: | 101137604
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