Information de reference pour ce titreAccession Number: | 00066773-200833020-00008.
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Author: | Thomas, Dimitrios; Karachaliou, Feneli; Kallergi, Konstantina; Vlachopapadopoulou, Elpis; Antonaki, Georgia; Chatzimarkou, Fotini; Fotinou, Aspasia; Kaldrymides, Philippos; Michalacos, Stefanos
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Institution: | Department of Endocrinology, Metabolism and Diabetes, ldquo;Metaxardquo; Memorial Anticancer Research Hospital, Botasi 51 Str, Piraeus, Greece (Thomas, Chatzimarkou, Kaldrymides) Department of Growth and Development, ldquo;P. &. A. Kyriakourdquo; Children's Hospital, Athens, Greece (Thomas, Karachaliou, Vlachopapadopoulou) Department of Microbiology, ldquo;P. & A. Kyriakourdquo; Children's Hospital, Athens, Greece (Kallergi, Antonaki, Fotinou)
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Title: | Herpes virus antibodies seroprevalence in children with autoimmune thyroid disease.[Article]
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Source: | Endocrine. 33(2):171-175, April 2008.
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Abstract: | Background: Elevated titers of antibodies against different herpes virus antigens have been reported in some immunodeficient and systemic autoimmune disorders.
Objective: To examine if Herpes Simplex Virus (HSV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) IgG and IgM antibodies are detected more frequently in children with autoimmune thyroid disease (AITD) compared to controls.
Subjects and methods: Thirty-four children with AITD, aged 9.62+/-2.35years, and 31 matched controls, aged 9.24+/-2.98years, were studied.
Results: The percentage of EBV IgG+ children with AITD was statistically higher than the percentage of EBV IgG+ controls (82.35% versus 51.61%, P=0.008). The percentage of EBV IgG+ children with AITD and hypothyroidism was statistically higher than the percentage of EBV IgG+ children with AITD, without hypothyroidism (100% versus 70%, P=0.024). No other statistically significant differences were observed in HSV-1+2, and CMV IgG or IgM antibodies between the subgroups of children studied.
Conclusions: EBV seroprevalence is higher in children with AITD compared to controls and the underlying pathology remains to be elucidated.
(C) 2008 Humana Press
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Author Keywords: | Autoimmune thyroiditis; Herpes virus; Seroprevalence.
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Language: | English.
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Document Type: | ORIGINAL PAPER: PDF Only.
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Journal Subset: | Clinical Medicine. Life Sciences.
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ISSN: | 0969-711X
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NLM Journal Code: | 9434444, CV9
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Annotation(s) | |