Information de reference pour ce titreAccession Number: | 00061310-200805000-00003.
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Author: | Griffith, Darren 1; Cecco, Sara 2; Zangrando, Ennio 3; Bergamo, Alberta 2; Sava, Gianni 2,4; Marmion, Celine J. 1
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Institution: | (1)Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland (2)Fondazione Callerio, Via A. Fleming 22-31 34127, Trieste, Italy (3)Dipartimento di Scienze Chimiche, Universita di Trieste, Via L. Giorgieri 1 34127, Trieste, Italy (4)Dipartimento di Scienze Biomediche, Universita di Trieste, Via L. Giorgieri 7-9 34127, Trieste, Italy
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Title: | Ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes as potential antimetastatic agents: synthesis, characterisation and in vitro pharmacological evaluation.[Article]
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Source: | Journal of Biological Inorganic Chemistry. 13(4):511-520, May 2008.
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Abstract: | Reaction of 3-pyridinehydroxamic acid and 4-pyridinehydroxamic acid (3-pyha and 4-pyha) with either [NBu4][RuCl4(dmso-S)2] or [(dmso)2H][RuCl4(dmso-S)2] (dmso is dimethyl sulfoxide) in acetone afforded three new ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes: [NBu4][trans-RuCl4(dmso-S)(4-pyha)][middle dot]CH3COCH3 (1), [3-pyhaH][trans-RuCl4(dmso-S)(3-pyha)] (2) and [4-pyhaH][trans-RuCl4(dmso-S)(4-pyha)] (3). The solid-state structure of [NBu4][trans-RuCl4(dmso-S)(4-pyha)][middle dot]CH3COCH3 (1) was determined by X-ray crystallography. 2 and 3 were pharmacologically evaluated for their in vitro cytotoxicity, their ability to inhibit cell invasion and their gelatinase activity. 2 and 3 were devoid of cytotoxicity against the cell lines tested. 2 inhibited invasion of the highly invasive MDA-MB-231 cells to a much greater extent than 3. Contrary to expectations, neither 2 nor 3 had any inhibitory effect on matrix metalloproteinase (MMP) production and/or activity and in fact 3 was found to enhance the production and/or activity of both MMP-2 and MMP-9.
(C) 2008 Springer. Part of Springer Science Business Media
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Author Keywords: | Ruthenium; Hydroxamic acid; Cytotoxicity; Metastasis; Matrix metalloproteinase.
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Language: | English.
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Document Type: | Original Paper: PDF Only.
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ISSN: | 0949-8257
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NLM Journal Code: | dgu, 9616326
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DOI Number: | https://dx.doi.org/10.1007/s0077...- ouverture dans une nouvelle fenêtre
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