Information de reference pour ce titreAccession Number: | 00006489-200701000-00005.
|
Author: | Harrod, Steven B. *; Booze, Rosemarie M.; Mactutus, Charles F.
|
Institution: | Department of Psychology, University of South Carolina, United States
|
Title: | |
Source: | Pharmacology, Biochemistry & Behavior. 86(1):32-36, January 2007.
|
Abstract: | Previous research demonstrates that repeated intravenous (IV) nicotine injection resulted in increased locomotor sensitization in female relative to male rats. In order to determine if increased nicotine levels are detected in females compared to males the present experiment examined the plasma nicotine levels of male, female, castrated (CAST), and ovariectomized (OVX) rats (n=7-11 rats/group) following repeated IV nicotine injection (50 [mu]g/kg/injection). All rats received 14 IV nicotine injections, one/day. Approximately 1 min after the 14th nicotine injection, rats were rapidly decapitated and trunk blood was collected immediately. Gas chromatography revealed a sex difference in nicotine content: higher plasma nicotine levels were measured from female rats (>10 x increase) relative to males, and the sex difference was attenuated by gonadectomy. These data suggest that the sex difference in plasma nicotine levels is due to alteration in distribution or nicotine metabolism as a function of circulating gonadal hormones. These findings indicate that gonadal hormones may influence nicotine pharmacokinetics and therefore nicotine-induced sex differences in behavior.
(C) 2007Elsevier, Inc.
|
Author Keywords: | Nicotine; Ovariectomy; Castration; Gas chromatography; Intravenous; Rats.
|
References: | Battig K. Smoking and the behavioral effects of nicotine. Trends Pharmacol Sci. 1981;2:145-147.
Benowitz NL, Kuyt F, Jacob P III. Circadian blood nicotine concentrations during cigarette smoking. Clin Pharmacol Ther. 1982;32(6):758-764.
Booze RM, Welch MA, Wood ML, Billings KA, Apple SR, Mactutus CF. Behavioral sensitization following repeated intravenous nicotine administration: gender differences and gonadal hormones. Pharmacol Biochem Behav. 1999;64(4):827-839.
Chaudhri N, Caggiula AR, Donny EC, Booth S, Gharib MA, Craven LA, et al. Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in rats. Psychopharmacology. 2005a;180(2):258-266.
Chaudhri N, Caggiula AR, Donny EC, Palmatier MI, Liu X, Sved AF. Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement. Psychopharmacology. 2005b;21:1-14.
Donny EC, Caggiula AR, Rowell PP, Gharib MA, Maldovan V, Booth S, et al. Nicotine self-administration in rats: estrous cycle effects, sex differences and nicotinic receptor binding. Psychopharmacology. 2000;151(4):392-405.
Downs AW, Eddy NB. The effect of repeated doses of cocaine on the rat. J Pharmacol Exp Ther. 1932;46:199-200.
Gandhi M, Aweeka F, Greenblatt RM, Blaschke TF. Sex differences in pharmacokinetics and pharmacodynamics. Ann Rev Pharmacol Toxicol. 2004;44:499-523.
Grunberg NE, Bowden DJ, Winders SE. Effects of nicotine on body weight and food consumption in female rats. Psychopharmacology. 1986;90:101-105.
Grunberg NE, Winders SE, Popp KA. Sex differences in nicotine's effects on consummatory behavior and body weight in rats. Psychopharmacology. 1987;91:221-225.
Harrod SB, Mactutus CF, Bennett K, Hasselrot U, Wu G, Welch M, et al. Sex differences and repeated intravenous nicotine: behavioral sensitization and dopamine receptors. Pharmacol Biochem Behav. 2004;78(3):581-592.
Jacob P III, Wilson M, Benowitz NL. Improved gas chromatographic method for the determination of nicotine and cotinine in biologic fluids. J Chromatogr. 1981;222:61-70.
Jacob P III, Yu L, Wilson M, Benowitz NL. Selected ion monitoring method for determination of nicotine, cotinine, and deuterium-labeled analogs: absence of an isotope effect in the clearance of (s)-nicotine-3',3'-d2 in humans. Biol Mass Spectrom. 1991;20:247-252.
Kalivas PW, Weber B. Amphetamine injection into the ventral mesencephalon sensitizes rats to peripheral amphetamine and cocaine. J Pharmacol Exp Ther. 1988;46245:1991095-1991102.
Kandel DB, Wu P, Davies M. Maternal smoking during pregnancy and smoking by adolescent daughters. Am J Public Health. 1994;84(9):1407-1413.
Kanyt L, Stolerman IP, Chandler CJ, Saigusa T, Pogun S. Influence of sex and female hormones on nicotine-induced changes in locomotor activity in rats. Pharmacol Biochem Behav. 1999;62(1):179-187.
Kyerematen GA, Owens GF, Chattopadhyay B, deBethizy JD, Vesell ES. Sexual dimorphism of nicotine metabolism and distribution in the rat. Studies in vivo and in vitro. Drug Metab Dispos. 1988;16(6):823-828, [1988 Nov-Dec].
Levin ED, Morgan MM, Galvez C, Ellison GD. Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats. Physiol Behav. 1987;39:441-444.
Mactutus CF, Herman AS, Booze RM. Chronic intravenous model for studies of drug (ab)use in the pregnant and/or group-housed rat: an initial study with cocaine. Neurotoxicol Teratol. 1994;16:183-191.
Post RM. Intermittent versus continuous stimulation: effect of time interval on the development of sensitization or tolerance. Life Sci. 1980;26:1275-1282.
Post RM, Contel NR. Human and animal studies of cocaine: implications for the development of behavioral pathology. In: Creese I, editor. Stimulants: neurochemical, behavioral and clinical perspectives. New York: Raven Press; 1983. p. 169-203.
Robinson TE, Berridge KC. Addiction. Annu Rev Psychol. 2003;54:25-53.
Rosecrans JA. Effects of nicotine on behavioral arousal and brain 5-hydroxytryptamine function in female rats selected for differences in activity. Eur J Pharmacol. 1971;14:29-37.
Rosecrans JA. Brain area nicotine levels in male and female rats with different levels of spontaneous activity. Neuropharmacology. 1972;11:863-870.
SPSS 12.0 for Windows (1989-2003). SPSS Inc.
Waldron I. Patterns and causes of gender differences in smoking. Soc Sci Med. 1991;32(9):989-1005.
Westermeyer J, Boedicker AE. Course, severity, and treatment of substance abuse among women versus men. Am J Drug Alcohol Abuse. 2000;26:532-535.
Winer BJ. Statistical Principles in Experimental Design. New York: McGraw-Hill; 1971.
Wonnacott S, Sidhpura N, Balfour DJ. Nicotine: from molecular mechanisms to behaviour. Curr Opin Pharmacol. 2005;5(1):53-59.
|
Language: | English.
|
Document Type: | Articles.
|
Journal Subset: | Pharmacology.
|
ISSN: | 0091-3057
|
NLM Journal Code: | p3q, 0367050
|
DOI Number: | https://dx.doi.org/10.1016/j.pbb...- ouverture dans une nouvelle fenêtre
|
Annotation(s) | |
|
|