Information de reference pour ce titreAccession Number: | 00001659-200612000-00001.
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Author: | Piotrowska, M. J. *,+,1; Widera, D. ++1; Kaltschmidt, B. ++; an der Heiden, U. *; Kaltschmidt, C. ++
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Institution: | *Institute of Mathematics, University of Witten/Herdecke, Stockumer Str. 10, 58448 Witten, Germany +Institute of Applied Mathematics and Mechanics, Department of Mathematics, Informatics and Mechanics, Warsaw University, Banacha 2, 02-097 Warsaw, Poland ++Institute for Neurobiochemistry, University of Witten/Herdecke, Stockumer Str. 10, 58448 Witten, Germany
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Title: | Mathematical model for NF-[kappa]B-driven proliferation of adult neural stem cells.[Article]
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Source: | Cell Proliferation. 39(6):441-455, December 2006.
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Abstract: | Abastract: Neural stem cells (NSCs) are early precursors of neuronal and glial cells. NSCs are capable of generating identical progeny through virtually unlimited numbers of cell divisions (cell proliferation), producing daughter cells committed to differentiation. Nuclear factor kappa B (NF-[kappa]B) is an inducible, ubiquitous transcription factor also expressed in neurones, glia and neural stem cells. Recently, several pieces of evidence have been provided for a central role of NF-[kappa]B in NSC proliferation control. Here, we propose a novel mathematical model for NF-[kappa]B-driven proliferation of NSCs. We have been able to reconstruct the molecular pathway of activation and inactivation of NF-[kappa]B and its influence on cell proliferation by a system of nonlinear ordinary differential equations. Then we use a combination of analytical and numerical techniques to study the model dynamics. The results obtained are illustrated by computer simulations and are, in general, in accordance with biological findings reported by several independent laboratories. The model is able to both explain and predict experimental data. Understanding of proliferation mechanisms in NSCs may provide a novel outlook in both potential use in therapeutic approaches, and basic research as well.
Copyright (C) 2006 Blackwell Publishing Ltd.
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Language: | English.
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Document Type: | Original Article.
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Journal Subset: | Life Sciences.
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ISSN: | 0960-7722
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NLM Journal Code: | a3a, 9105195
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