Information de reference pour ce titreAccession Number: | 00000429-200612010-00002.
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Author: | Savitz, David A. 1,2; Singer, Philip C. 3; Herring, Amy H. 4; Hartmann, Katherine E. 1,5; Weinberg, Howard S. 3; Makarushka, Christina 1
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Institution: | (1)Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC (3)Department of Environmental Sciences and Engineering, University of North Carolina School of Public Health, Chapel Hill, NC (4)Department of Biostatistics, University of North Carolina School of Public Health, Chapel Hill, NC (5)Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC
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Title: | |
Source: | American Journal of Epidemiology. 164(11):1043-1051, December 2006.
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Abstract: | Previous research has suggested that exposure to elevated levels of drinking water disinfection by-products (DBPs) may cause pregnancy loss. In 2000-2004, the authors conducted a study in three US locations of varying DBP levels and evaluated 2,409 women in early pregnancy to assess their tap water DBP concentrations, water use, other risk factors, and pregnancy outcome. Tap water concentrations were measured in the distribution system weekly or biweekly. The authors considered DBP concentration and ingested amount and, for trihalomethanes only, bathing/showering and integrated exposure that included ingestion. On the basis of 258 pregnancy losses, they did not find an increased risk of pregnancy loss in relation to trihalomethane, haloacetic acid, or total organic halide concentrations; ingested amounts; or total exposure. In contrast to a previous study, pregnancy loss was not associated with high personal trihalomethane exposure (>=75 [mu]g/liter and >=5 glasses of water/day) (odds ratio=1.1, 95% confidence interval: 0.7, 1.7). Sporadic elevations in risk were found across DBPs, most notably for ingested total organic halide (odds ratio=1.5, 95% confidence interval: 1.0, 2.2 for the highest exposure quintile). These results provide some assurance that drinking water DBPs in the range commonly encountered in the United States do not affect fetal survival.
(C) Johns Hopkins School of Hygiene and Public Health 2006. Published by Oxford University Press. All rights reserved.
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Author Keywords: | abortion, spontaneous; pregnancy; water pollutants.
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Language: | English.
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Document Type: | ORIGINAL CONTRIBUTION.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0002-9262
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NLM Journal Code: | 3h3, 7910653
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