Information de reference pour ce titreAccession Number: | 00007670-200604000-00022.
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Author: | Silvestrini, Mauro MD; Pasqualetti, Patrizio PhD; Baruffaldi, Roberto MD; Bartolini, Marco MD; Handouk, Yasmin MD; Matteis, Maria PhD; Moffa, Filomena PhD; Provinciali, Leandro MD; Vernieri, Fabrizio MD
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Institution: | From the Neurological Clinic (M.S., R.B., M.B., Y.H., L.P.), Polytechnic University of Marche, Ancona, Italy; Department of Neuroscience (P.P., F.M.), AfaR-Fatebenefratelli Hospital, Isola Tiberina, Roma, Italy; IRCCS Fondazione Santa Lucia (M.M.), Roma, Italy; and Neurological Clinic (F.V.), Campus Biomedico University, Roma, Italy.
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Source: | Stroke. 37(4):1010-1015, April 2006.
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Abstract: | Background and Purpose-: The aim of this study was to explore the possible contribution of alterations in cerebral hemodynamics to the evolution of cognitive impairment in patients with Alzheimer disease (AD).
Method-: Fifty-three patients with AD were investigated. The evolution of cognitive decline over 12 months was evaluated by means of changes in Mini Mental State Examination (MMSE) and AD Assessment Scale for Cognition (ADAS-Cog) scores. Demographic characteristics, vascular risk profile, pharmacological treatment, and presence of white matter lesions were assessed at entry. Further, a basal evaluation of cerebrovascular reactivity to hypercapnia was measured with transcranial Doppler ultrasonography using the breath-holding index (BHI).
Results-: Of all the variables considered, both MMSE and ADAS-Cog changes had the highest correlation with BHI, followed by age and diabetes. After subdividing both cognitive measures reductions into bigger and smaller-than-average decline (2 points for MMSE; 5 points for ADAS-Cog), multiple logistic regression indicated BHI as the sole significant predictor of cognitive decline.
Conclusions-: These results show an association between impaired cerebral microvessels functionality and unfavorable evolution of cognitive function in patients with AD. Further research is needed to fully establish whether altered cerebral hemodynamics may be considered an independent factor in sustaining cognitive decline progression or an effect of pathological processes involved in AD.
(C) 2006 American Heart Association, Inc.
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Author Keywords: | dementia; hemodynamics; ultrasonography; ultrasonography, Doppler, transcranial.
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Language: | English.
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Document Type: | Original Contributions.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0039-2499
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NLM Journal Code: | v2j, 0235266
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DOI Number: | https://dx.doi.org/10.1161/01.ST...- ouverture dans une nouvelle fenêtre
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