Information de reference pour ce titreAccession Number: | 01253034-200601000-00013.
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Author: | Janzen, William P. *; Hodge, C. Nicholas
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Institution: | Amphora Discovery Corporation, 800 Capitola Drive, Durham, NC 27713, USA
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Title: | |
Source: | Chemical Biology & Drug Design. 67(1):85-86, January 2006.
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Abstract: | An approach is described for identifying scaffolds with predefined selectivity profiles directly from a high-quality high-throughput screening data set, and monitoring that selectivity profile throughout the drug discovery process. This approach results in reduced drug development timelines from 'hit' to 'lead' stage, and should reduce liabilities for a molecule advancing through the development process.
Copyright (C) 2006 Blackwell Publishing Ltd.
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References: | 1. Janzen W., Bernasconi P., Cheatham, L., Mansky P., Popa-Burke I., Williams K., Worley J., Hodge N. (2004) Optimizing the chemical genomics process. In: Darvas X, Guttman X, Dorman X, editors. Chemical Genomics: Advances in Drug Discovery and Functional Genomics Applications. New York: Marcel Dekker, p.59-100.
2. Popa-Burke I., Birkos, S., Blackwell L., Cheatham L., Clark J., Dickson J.K., Galasinski S., Janzen W.P., Mendoza J., Miller J., Mohney R.P., Hodge C.N. (2005) Discovery of highly selective inhibitors of p38[alpha]. Curr Topics Med Chem;5:941-951.
3. Popa-Burke, I.G., Issakova O., Arroway J.D., Bernasconi P., Chen M., Coudurier L., Galasinski S., Janzen W.P., Lagasca D., Liu D., Lewis R.S., Mohney R.P., Sepetov N., Sparkman D.A., Hodge C.N. (2004) Streamlined system for purifying and quantifying a diverse library of compounds and the effect of compound concentration measurements on the accurate interpretation of biological assay results. Anal Chem;76:7278-7287.
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Language: | English.
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Document Type: | R & D Technology Forum.
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Journal Subset: | Life Sciences.
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ISSN: | 1747-0277
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NLM Journal Code: | 101262549
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