Information de reference pour ce titreAccession Number: | 00042855-200630010-00004.
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Author: | Mathelier-Fusade, Pascale
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Institution: | Centre d'Allergologie, Hopital Tenon, Paris, France. E-mail: [email protected].
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Title: | Drug-Induced Urticarias.[Article]
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Source: | Clinical Reviews in Allergy & Immunology. 30(1):19-23, February 2006.
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Abstract: | Drugs may cause urticaria by different mechanisms. The most well-known mechanism is the allergic reaction mediated by immunoglobulin (Ig)E antibodies, which induce acute generalized urticaria. Allergic reactions to [beta]-lactams are the most common cause of adverse drug reaction mediated by IgE antibodies. However, IgE antibodies are not always necessary to activate the release of mediators from mast cells and induce acute urticarias. Some drugs, such as opiates or codeine, act directly on mast cells, and others, such as aspirin and nonsteroidal anti-inflammatories, induce an exacerbation of chronic urticaria by a pharmacological mechanism involving the arachidonic acid metabolism. Additionally, angioedema is a wellknown complication of angiotensin-converting enzyme inhibitors by its action on bradykinin, which is a potent vasodilatator agent. Topical drugs, such as antibiotics, disinfectants, or anesthetics, may cause urticaria, which sometimes progresses to generalized urticaria and, more rarely, to anaphylactoid reactions.
(C) 2006 Humana Press
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Author Keywords: | Urticaria; angioedema; aspirin; nonsteroidal anti-inflammatory drugs; angiotensin-converting enzyme inhibitors.
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Language: | English.
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Document Type: | ORIGINAL ARTICLE: PDF Only.
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Journal Subset: | Clinical Medicine.
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ISSN: | 1080-0549
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NLM Journal Code: | ca0, 9504368
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Annotation(s) | |