Information de reference pour ce titreAccession Number: | 00019521-200505010-00017.
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Author: | Proskocil, Becky J.; Sekhon, Harmanjatinder S.; Clark, Jennifer A.; Lupo, Stacie L.; Jia, Yibing; Hull, William M.; Whitsett, Jeffrey A.; Starcher, Barry C.; Spindel, Eliot R.
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Institution: | Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton; Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon; Department of Pathology, Harborview Medical Center, Seattle, Washington; Divisions of Neonatology and Pulmonary Biology, Children's Hospital, Cincinnati, Ohio; and Department of Biochemistry, University of Texas Health Center at Tyler, Tyler, Texas
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Title: | |
Source: | American Journal of Respiratory & Critical Care Medicine. 171(9):1032-1039, May 1, 2005.
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Abstract: | : Smoking during pregnancy leads to decreased pulmonary function and increased respiratory illness in offspring. Our laboratory has previously demonstrated that many effects of smoking during pregnancy are mediated by nicotine. We now report that vitamin C supplementation can prevent some of the effects of maternal nicotine exposure on pulmonary function of offspring. Timed-pregnant rhesus monkeys were treated with 2 mg/kg/day nicotine bitartrate from Gestation Days 26 to 160. On Gestation Day 160 (term, 165 days) fetuses were delivered by C-section and subjected to pulmonary function testing the following day. Nicotine exposure significantly reduced forced expiratory flows, but supplementation of mothers with 250 mg vitamin C per day prevented the effects of nicotine on expiratory flows. Vitamin C supplementation also prevented the nicotine-induced increases in surfactant apoprotein-B protein. Neither nicotine nor nicotine plus vitamin C significantly affected levels of cortisol or cytokines, which have been shown to affect lung development and surfactant expression. Prenatal nicotine exposure significantly decreased levels of elastin content in the lungs of offspring, and these effects were slightly attenuated by vitamin C. These findings suggest that vitamin C supplementation may potentially be clinically useful to limit the deleterious effects of maternal smoking during pregnancy on offspring's lung function.
(C) 2005 American Thoracic Society
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Author Keywords: | elastin; lung; pregnancy; smoking; surfactant.
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Language: | English.
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Document Type: | F. Environmental and Occupational Lung Disease: PDF Only.
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Journal Subset: | Clinical Medicine.
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ISSN: | 1073-449X
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NLM Journal Code: | 9421642, bzs
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DOI Number: | https://dx.doi.org/10.1164/rccm....- ouverture dans une nouvelle fenêtre
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