Information de reference pour ce titreAccession Number: | 00001640-200311000-00006.
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Author: | Kotak, Vibhakar C. 1; Sanes, Dan H. 1
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Institution: | (1)Center for Neural Science, New York University, 4 Washington Place, Room 809, New York, NY 10003 USA
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Title: | Gain adjustment of inhibitory synapses in the auditory system.[Article]
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Source: | Biological Cybernetics. 89(5):363-370, November 2003.
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Abstract: | : A group of central auditory neurons residing in the lateral superior olivary nucleus (LSO) responds selectively to interaural level differences and may contribute to sound localization. In this simple circuit, ipsilateral sound increases firing of LSO neurons, whereas contralateral sound inhibits the firing rate via activation of the medial nucleus of the trapezoid body (MNTB). During development, individual MNTB fibers arborize within the LSO, but they undergo a restriction of their boutons that ultimately leads to mature topography. A critical issue is whether a distinct form of inhibitory synaptic plasticity contributes to MNTB synapse elimination within LSO. Whole-cell recording from LSO neurons in brain slices from developing gerbils show robust long-term depression (LTD) of the MNTB-evoked IPSP/Cs when the MNTB was activated at a low frequency (1 Hz). These inhibitory synapses also display mixed GABA/glycinergic transmission during development, as assessed physiologically and immunohistochemically (Kotak et al. 1998). While either glycine or GABAA receptors could independently display inhibitory LTD, focal delivery of GABA, but not glycine, at the postsynaptic-locus induces depression. Furthermore, the GABAB receptor antagonist, SCH-50911, prevents GABA or synaptically induced depression. Preliminary evidence also indicated strengthening of inhibitory transmission (LTP) by a distinct pattern of inhibitory activity. These data support the idea that GABA is crucial for the expression inhibitory LTD and that this plasticity may underlie the early refinement of inhibitory synaptic connections in the LSO.
(C) 2003 Springer. Part of Springer Science Business Media
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Language: | English.
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Document Type: | Article: PDF Only.
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Journal Subset: | Life & Biomedical Sciences.
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ISSN: | 0340-1200
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NLM Journal Code: | a2h, 7502533
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DOI Number: | https://dx.doi.org/10.1007/s...- ouverture dans une nouvelle fenêtre
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