Information de reference pour ce titreAccession Number: | 00005064-200212050-00007.
|
Author: | Nixon, Kimberly; Crews, Fulton T. *
|
Institution: | (*)Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
|
Title: | |
Source: | Journal of Neurochemistry. 83(5):1087-1093, December 2002.
|
Abstract: | Alcoholism is associated with cognitive deficits and loss of brain mass. Recent studies have indicated that neural progenitor cells proliferate throughout life forming neurons, astrocytes, and oligodendrocytes. The dentate gyrus is one neurogenic region of the adult brain containing neural progenitor cells. To determine if binge ethanol (EtOH) exposure alters neural progenitor cell proliferation and survival, bromodeoxyuridine was administered to adult male rats following an acute or chronic binge exposure paradigm. For an acute binge, rats were gavaged with a 5 g/kg dose of EtOH or vehicle, administered bromodeoxyuridine, and killed either 5 h or 28 days after EtOH treatment. In a 4-day, chronic-binge paradigm, rats were infused with EtOH three times per day (mean dose 9.3 g/kg/day) or isocaloric control diet. Rats were given bromodeoxyuridine once a day for the 4 days of chronic binge treatment, then perfused either immediately following the last dose of EtOH or 28 days later. In both EtOH treatment groups, binge EtOH decreased neural progenitor cell proliferation. Following the chronic four-day binge, neural progenitor cell survival was decreased. These studies are the first to show EtOH inhibition of neural progenitor cell proliferation and survival in the adult, a possible new mechanism underlying alcoholic cognitive dysfunction.
(C) 2002 International Society for Neurochemistry
|
Author Keywords: | alcohol; brain; dentate gyrus; ethanol; neurogenesis; stem cell.
|
References: | Agartz I., Momenan R., Rawlings R. R., Kerich M. J. and Hommer D. W. (1999) Hippocampal volume in patients with alcohol dependence. Arch. Gen. Psych. 56, 356-363.
Bayer S. A., Yackel J. W. and Puri P. S. (1982) Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life. Science 216, 890-892.
Bonthius D. J. and West J. R. (1990) Alcohol-induced neuronal loss in developing rats: Increased brain damage with binge exposure. Alcohol Clin. Exp. Res. 14, 107-118.
Cameron H. A. and McKay R. D. (2001) Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol. 435, 406-417.
Collins M. A., Corso T. D. and Neafsey E. J. (1996) Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic 'binge' intoxication with ethanol: possible explanation for olfactory deficits in alcoholics. Alcohol Clin. Exp. Res. 20, 284-292.
Crews F. T. (1999) Alcohol and neurodegeneration. CNS Drug Rev. 5, 379-394.
Crews F. T. (2000) Neurotoxicity of alcohol: Excitotoxicity, oxidative stress, neurotrophic factors, apoptosis, and cell adhesion molecules, in Review of NIAAA's Neuroscience and Behavioral Research Portfolio, Monograph No. 34 (Noronha M., Eckardt M. and Warren K., eds), pp. 189-206. National Institutes of Health, Bethesda, MD.
Crews F. T., Braun C. J., Switzer R. C. III and Knapp D. J. (2000) Binge ethanol causes differential brain damage in young adolescent rats compared to adult rats. Alcohol Clin. Exp. Res. 24, 1712-1723.
Dolbeare F. (1995) Bromodeoxyuridine: a diagnostic tool in biology and medicine. Part I: Historical perspectives, histochemical methods and cell kinetics. Histochem. J. 27, 339-369.
Dunty W. C. Jr, Chen S. Y., Zucker R. M., Dehart D. B. and Sulik K. K. (2001) Selective vulnerability of embryonic cell populations to ethanol-induced apoptosis: Implications for alcohol-related birth defects and neurodevelopmental disorder. Alcohol Clin. Exp. Res. 25, 1523-1235.
Eckardt M. J. and Martin P. R. (1986) Clinical assessment of cognition in alcoholism. Alcohol Clin. Exp. Res. 10, 123-127.
Fadda F. and Rossetti Z. (1998) Chronic ethanol consumption: From neuroadaptation to neurodegeneration. Prog. Neurobiol. 56, 385-431.
Gage F. H. (2000) Mammalian neural stem cells. Science 287, 1433-1438.
Gage F. H. and Song H. J. (2002) Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. J. Am. Acad. Child Adolesc. Psychiatry 41, 354-356.
Goodlett C. R. and Horn K. H. (2001) Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol Res. Health 25, 175-184.
Goodlett C. R. and Johnson T. B. (1999) Temporal windows of vulnerability within the third trimester equivalent: Why 'knowing when' matters, in Alcohol and Alcoholism: Effects on Brain Development (Hannigan J. H., Spear L. P., Spear N. E. and Goodlett C. R., eds), pp. 1-16. Lawrence Erlbaum Associates, New Jersey.
Gould E. and Gross C. G. (2002) Neurogenesis in adult mammals: Some progress and problems. J. Neurosci. 22, 619-623.
Gould E., Beylin A., Tanapat P., Reeves A. and Shors T. J. (1999) Learning enhances adult neurogenesis in the hippocampal formation. Nat. Neurosci. 2, 260-265.
Harding A. J., Wong A., Svoboda M., Kril J. J. and Halliday G. M. (1997) Chronic alcohol consumption does not cause hippocampal neuron loss in humans. Hippocampus 7, 78-87.
Harper C. G., Kril J. J. and Daly J. (1987) Are we drinking our neurons away? Br. Med. J. 294, 534-536.
Hunt W. A. (1993) Are binge drinkers more at risk of developing brain damage? Alcohol 10, 559-561.
Jacobs J. S. and Miller M. W. (2001) Proliferation and death of cultured fetal neocortical neurons: Effects of ethanol on dynamics of cell growth. J. Neurocytol. 30, 391-401.
Kempermann G. (2002) Why new neurons? Possible functions for adult hippocampal neurogenesis. J. Neurosci. 22, 635-638.
Kempermann G., Brandon E. P. and Gage F. H. (1998a) Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus. Curr. Biol. 8, 939-942.
Kempermann G., Kuhn H. G. and Gage F. H. (1998b) Experience-induced neurogenesis in the senescent dentate gyrus. J. Neurosci. 18, 3206-3212.
Knapp D. J. and Crews F. T. (1999) Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal. Alcohol Clin. Exp. Res. 23, 633-643.
Kuhn H. G., Jurgen W., Kempermann G., Thal L. J. and Gage F. H. (1997) Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J. Neurosci. 17, 5820-5829.
Lukoyanov N. V., Brandao F., Cadete-Leite A., Madeira M. D. and Paula-Barbosa M. M. (2000) Synaptic reorganization in the hippocampal formation of alcohol-fed rats may compensate for functional deficits related to neuronal loss. Alcohol 20, 139-148.
Majchrowicz E. (1975) Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia 43, 245-254.
Marcussen B. L., Goodlett C. R., Mahoney J. C. and West J. R. (1994) Developing rat Purkinje cells are more vulnerable to alcohol-induced depletion during differentiation than during neurogenesis. Alcohol 11, 147-156.
Miller M. W. (1986) Effects of alcohol on the generation and migration of cerebral cortical neurons. Science 233, 1308-1311.
Miller M. W. (1995) Generation of neurons in the rat dentate gyrus and hippocampus: Effects of perinatal and postnatal treatment with ethanol. Alcohol Clin. Exp. Res. 17, 304-314.
Miller M. W. and Nowakowski R. S. (1991) Effect of prenatal exposure to ethanol on the cell cycle kinetics and growth fraction in the proliferative zones of fetal rat cerebral cortex. Alcohol Clin. Exp. Res. 15, 229-232.
Nottebohm F. (2002) Why are some neurons replaced in adult brain? J. Neurosci. 22, 624-628.
Obernier J. A., Bouldin T. W. and Crews F. T. (2002a) Binge ethanol exposure in adult rats causes necrotic cell death. Alcohol Clin. Exp. Res. 26, 547-557.
Obernier J. A., White A. M., Swartzwelder H. S. and Crews F. T. (2002b) Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. Pharmacol. Biochem. Behav. 72, 521-532.
Palmer T. D., Willhoite A. R. and Gage F. H. (2000) Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 425, 479-494.
Pfefferbaum A., Kim K. O., Zipursky R. B., Mathalon D. H., Lane B., Ha C. N., Rosenbloom M. J. and Sullivan E. V. (1992) Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: A quantitative MRI study. Alcohol Clin. Exp. Res. 16, 1078-1089.
Phillips S. C., Harper C. G. and Kril J. (1987) A quantitative histological study of the cerebellar vermis in alcoholic patients. Brain 110, 301-314.
van Praag H., Schinder A. F., Christie B. R., Toni N., Palmer T. D. and Gage F. H. (2002) Functional neurogenesis in the adult hippocampus. Nature 415, 1030-1034.
Shors T. J., Miesegaes G., Beylin A., Zhao M., Rydel T. and Gould E. (2001) Neurogenesis in the adult is involved in the formation of trace memories. Nature 410, 372-376.
Sterio D. C. (1984) The unbiased estimation of number and sizes of arbitrary particles using the disector. J. Microsc. 134, 127-136.
Sullivan E. V., Marsh L., Mathalon D. H., Lim K. O. and Pfefferbaum A. (1995) Anterior hippocampal volume deficits in non-amnesic, aging chronic alcoholics. Alcohol Clin. Exp. Res. 19, 110-122.
Walker D. W., Barnes D. E., Zornetzer S. F., Hunter B. E. and Kubanis P. (1980) Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats. Science 209, 711-713.
Wang S., Scott B. W. and Wojtowicz J. M. (2000) Heterogeneous properties of dentate granule neurons in the adult rat. J. Neurobiol. 42, 248-257.
West M. J. (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231, 482-497.
Wimer R. E., Wimer C. C. and Alameddine L. (1988) On the development of strain and sex differences in granule cell number in the area dentata of house mice. Brain Res. 470, 191-197.
|
Language: | English.
|
Document Type: | Original Articles.
|
Journal Subset: | Clinical Medicine. Behavioral & Social Sciences.
|
ISSN: | 0022-3042
|
NLM Journal Code: | jav, 2985190r
|
Annotation(s) | |
|
|