Information de reference pour ce titreAccession Number: | 01451459-200208150-00007.
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Author: | Gerber, Angela 1; Karch, Helge 2; Allerberger, Franz 3; Verweyen, Hege M. 1; Zimmerhackl, Lothar B. 1,a
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Institution: | (1)Zentrum fur Kinderheilkunde und Jugendmedizin, Universitat Freiburg, Freiburg, and (2)Institut fur Hygiene, Universitat Munster, Munster, Germany; (3)Institut fur Hygiene, Universitat Innsbruck, Innsbruck, Austria
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Source: | Journal of Infectious Diseases. 186(4):493-500, August 15, 2002.
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Abstract: | : Hemolytic-uremic syndrome (HUS) is mainly associated with foodborne infections by Shiga toxin-producing Escherichia coli (STEC). From January 1997 through December 2000, 394 children with HUS were evaluated in a prospective multicenter surveillance study in Germany and Austria (incidences, 0.7/100,000 and 0.4/100,000 children <15 years old, respectively). Blood leukocytosis was associated with increased detection of STEC in stool cultures (P<.01) and a more severe disease course. Risk of death was associated with cerebral involvement (P<.01). Most strikingly, non-O157:H7 STEC were detected in 43% of stool cultures of patients with HUS: O26 was detected in 15%, sorbitol-fermenting O157:H- in 10%, O145 in 9%, O103 in 3%, and O111 in 43%. Patients with O157:H7 serotypes required dialysis for a longer time and had bloody diarrhea detected more frequently, compared with patients with non-O157:H7 serotypes (P<.05). This large study in children with HUS underlines the rising importance of non-O157:H7 serotypes, and, despite increased public awareness, the number of patients remained unchanged.
(C) Copyright Oxford University Press 2002.
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Language: | English.
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Document Type: | Major Articles.
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ISSN: | 0022-1899
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DOI Number: | https://dx.doi.org/10.1086/34194...- ouverture dans une nouvelle fenêtre
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