Information de reference pour ce titreAccession Number: | 00003040-200108000-00022.
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Author: | Balding, C. E. J. 1; Howie, A. J. 2; Drake-Lee, A. B. 3; Savage, C. O. S. 1
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Institution: | (1)Renal Immunobiology Laboratory, Division of Medical Sciences, MRC Centre for Immune Regulation, (2)Department of Pathology, The Medical School,University of Birmingham, Birmingham, and (3)ENT Department, University Hospital, Birmingham, UK
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Title: | |
Source: | Clinical & Experimental Immunology. 125(2):332-339, August 2001.
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Abstract: | Wegener's granulomatosis initially affects upper respiratory tract organs including the nasal mucosa in more than 90% of patients. The inflammation is typically granulomatous with associated vasculitis. T lymphocytes are usually a prominent component of the leucocyte infiltrate. Previous studies using peripheral blood T cells have implicated IFN-[gamma] rich Th1-type responses. This study addressed the cytokine milieu in nasal mucosa from 10 patients with active Wegener's granulomatosis using immunohistochemistry. Increased levels of CD3+ T cells and eosinophils were present compared with normal and disease controls. There was increased expression of IL-4, down-regulation of IL-2 and no detectable IFN-[gamma]. There was increased expression of the chemokine receptor CCR3 by infiltrating cells, consistent with an IL-4 dominant, Th2-biased response. In contrast, renal biopsy tissue from 10 patients with active Wegener's granulomatosis showed expression of IL-2 and IL-4. The Th2-type environment within nasal mucosa, often the initial site of disease activity in Wegener's, is consistent with a local allergic response in these patients.
(C) 2001 Blackwell Science Ltd.
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Author Keywords: | cytokines; kidney; vasculitis.
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Language: | English.
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Document Type: | Rheumatic disease/vasculitis.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0009-9104
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NLM Journal Code: | dd7, 0057202
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