Information de reference pour ce titreAccession Number: | 00005625-200105000-00006.
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Author: | Dispenzieri, Angela MD; Gertz, Morie A. MD; Therneau, Terry M. PhD; Kyle, Robert A. MD
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Institution: | From the Division of Hematology and Internal Medicine (A.D., M.A.G., R.A.K.) and Section of Biostatistics (T.M.T.), Mayo Clinic, Rochester, Minn.
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Title: | Retrospective Cohort Study of 148 Patients With Polyclonal Gammopathy.[Article]
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Source: | Mayo Clinic Proceedings. 76(5):476-487, May 2001.
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Abstract: | Objective: To quantify clinical conditions and laboratory values associated with moderate to marked polyclonal gammopathy.
Patients and Methods: Patient characteristics, laboratory correlates, evolving disease states, and survival of all patients seen at the Mayo Clinic, Rochester, Minn, during 1991 with a polyclonal gamma globulin level of 3.0 g/dL or higher were reviewed in this retrospective cohort study.
Results: One hundred forty-eight patients were identified (median age, 58 years; 59% female). In 130 patients (88%), only 1 diagnosis was identified, Liver disease was the most common single disease association in 79 (61%) of 130 patients, followed by connective tissue diseases in 28 (22%), chronic infections in 8 (6%), hematologic disorders in 6 (5%), and nonhematologic malignancies in 4 (3%). No difference in gamma globulin levels existed between groups. With a median follow-up of 67 months, 90 (63%) of 143 patients for whom follow-up was available were alive. By multivariate analysis, age, albumin concentration, disease group, and platelet count were predictive of survival. No patient developed myeloma or a clonal plasmaproliferative disorder.
Conclusion: Moderate to marked polyclonal gammopathy may reflect an underlying condition: liver disease, connective tissue disease, hematologic disorder, infection, or malignancy.
(C) 2001 Mayo Foundation for Medical Education and Research
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Language: | English.
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Document Type: | Original Article.
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Journal Subset: | Clinical Medicine. Behavioral & Social Sciences.
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ISSN: | 0025-6196
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NLM Journal Code: | 0405543, lly
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