Information de reference pour ce titreAccession Number: | 00004424-200104000-00003.
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Author: | VIETH, VOLKER MD *; LINK, THOMAS M. MD *+; LOTTER, ALBRECHT PhD *; PERSIGEHL, THORSTEN BS *; NEWITT, DAVID PhD +; HEINDEL, WALTER MD *; MAJUMDAR, AND SHARMILA PhD +
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Institution: | From the *Department of Clinical Radiology, University of Muenster, Muenster Germany, and the +Magnetic Resonance Science Center, Department of Radiology, University of California at San Francisco, San Francisco, California.
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Title: | |
Source: | Investigative Radiology. 36(4):210-217, April 2001.
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Abstract: | Vieth V, Link TM, Lotter A, et al. Does the trabecular bone structure depicted by high-resolution MRI of the calcaneus reflect the true bone structure? Invest Radiol 2001;36:210-217.
rationale and objectives. The purpose of this study was to compare trabecular bone structure parameters assessed with high-resolution magnetic resonance imaging (HR-MRI) with those determined in specimen sections.
methods. High-resolution MR images were obtained for 30 calcaneus specimens with a three-dimensional, T1-weighted spin-echo sequence (spatial in-plane resolution 0.195 mm, slice thicknesses of 0.3 and 0.9 mm). Thirty-eight sections were obtained from the specimens, and contact radiography was performed. In the corresponding sections, structural parameters analogous to bone histomorphometry were determined.
results. Significant correlations between MRI-derived structural parameters and those derived from macro pathological sections were found:r values of up to 0.75 were obtained (P < 0.01). The highest correlations were found for apparent bone volume/total volume and trabecular thickness. Image thresholding techniques showed a significant impact on these correlations (P < 0.01). The thinner MR sections were less susceptible to the different thresholding algorithms.
conclusions. Trabecular bone structure depicted by HR-MR images is significantly correlated with that shown in macro sections (P < 0.01); however, a number of limitations have to be considered, including the substantial impact of thresholding techniques and slice thickness.
(C) 2001 Lippincott Williams & Wilkins, Inc.
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Author Keywords: | High-resolution MRI; texture analysis; trabecular bone; osteoporosis; calcaneus..
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Language: | English.
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Document Type: | Original Investigations.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0020-9996
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NLM Journal Code: | gwk, 0045377
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