Information de reference pour ce titreAccession Number: | 01451459-200010000-00028.
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Author: | Hurwitz, Eugene S. 1; Haber, Michael 2; Chang, Albert 3; Shope, Timothy 4; Teo, Siew T. 5; Giesick, Jill S. 5; Ginsberg, Michele M. 5; Cox, Nancy J. 1
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Institution: | (1)Centers for Disease Control and Prevention, Atlanta, Georgia (2)Emory University, Atlanta, Georgia (3)San Diego State University, San Diego, California (4)San Diego Naval Medical Center, San Diego, California (5)San Diego County Health Department, San Diego, California
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Title: | |
Source: | Journal of Infectious Diseases. 182(4):1218-1221, October 2000.
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Abstract: | : A randomized, blinded, pilot study of influenza vaccine administered to children attending day care centers was conducted during the 1996-1997 winter. Vaccine efficacy in preventing serologically proven influenza virus infection was 0.45 (95% confidence limit [CL]: -0.02, 0.69) for influenza B and 0.31 (95% CL: -0.95, 0.73) for influenza A(H3N2). For both influenza A(H3N2) and B, children without preexisting hemagglutination inhibition (HI) antibody to these antigens had lower antibody responses to vaccine, were less likely to develop a serological response, and were more likely to develop serological evidence of influenza infection. Although there were no reductions in respiratory or febrile respiratory illnesses among all vaccinated children, there was a trend for reductions in such illnesses among vaccinated children with preexisting HI antibodies to influenza A(H3N2) and B. Therefore, immunologic priming in young children may be important for vaccine response and for protection against infection. Larger studies are needed in other influenza seasons to assess vaccine efficacy and clinical effectiveness.
(C) Copyright Oxford University Press 2000.
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Language: | English.
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Document Type: | Concise Communications.
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ISSN: | 0022-1899
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DOI Number: | https://dx.doi.org/10.1086/31582...- ouverture dans une nouvelle fenêtre
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