Information de reference pour ce titreAccession Number: | 00023727-199911000-00001.
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Author: | Tsuang, Ming T. MD, PhD, DSc, FRCPsych 1,2,3,4,6; Stone, William S. PhD 1,2,3,6; Faraone, Stephen V. PhD 1,2,3,5,6
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Institution: | (1)Harvard Medical School Department of Psychiatry, Boston, Mass. (2)Massachusetts Mental Health Center, Boston, Mass. (3)Brockton-West Roxbury Veterans Affairs Medical Center, Brockton, Mass. (4)Department of Epidemiology, Harvard School of Public Health, Boston, Mass. (5)Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, Mass. (6)Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, Mass.
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Title: | |
Source: | Harvard Review of Psychiatry. 7(4):185-207, November/December 1999.
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Abstract: | : Despite the complexities of schizophrenia, notable progress has been achieved in its diagnosis and treatment over the last 25 years. In this article we review the genetic research that provides the foundation for continued advances. One of the bases of our current understanding involves the observation that schizophrenia often runs in families. The development and utilization of stringent, reliable diagnostic criteria, together with the advent of modern family, twin, and adoption paradigms, demonstrate the importance of genetic factors in understanding the familial basis of the disorder. Refinements in diagnostic criteria have also enabled advances in understanding the likely mode--or modes--of genetic transmission of both schizophrenia and related disorders. After reviewing representative studies in these areas, we examine genetic linkage studies and our progress toward identifying the genes that cause schizophrenia. Although consistent results have been difficult to obtain and much work remains to be done, evidence for areas of vulnerability has been converging at particular chromosomal sites (e.g., 6p, 8p, and 22q), allowing for cautious optimism. Finally, we discuss challenges and prospects for the new millennium, including the clinical and ethnical implications of genetic investigations.
(C) 1999 President and Fellows of Harvard College
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Language: | English.
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Document Type: | Research Article: PDF Only.
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Journal Subset: | Clinical Medicine. Behavioral & Social Sciences.
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ISSN: | 1067-3229
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NLM Journal Code: | cow, 9312789
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DOI Number: | https://dx.doi.org/10.3109/hrp.7...- ouverture dans une nouvelle fenêtre
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