Coexistence of Hepatocellular Carcinoma (HCC) and c-Kit Negative Gastrointestinal Stromal Tumor (GIST): A Case Report.
Felekouras, Evangelos MD; Athanasios, Petrou MD; Vgenopoulou, Stefani MD; Papaconstantinou, Ioannis MD; Prassas, Evangelos MD; Giannopoulos, Athanasios MD; Griniatsos, John MD
[Report] Southern Medical Journal. 101(9):948-951, September 2008.

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A past history of sporadic solid cancers is disclosed in 10% of gastrointestinal stromal tumor (GIST) patients. Simultaneous occurrence with other malignancies is encountered in 14 to 16%, but the synchronous occurrence of GIST and hepatocellular carcinoma (HCC) has been reported only once in the English literature. An 81-year-old male patient is presented with a preoperatively known HCC, in whom a synchronous small nodular omental GIST adjacent to the lesser curvature of the stomach was incidentally discovered. When a GIST is encountered, a thorough intraoperative investigation of the abdominal cavity currently remains the only reliable method for detection of a possible coexisting malignancy.

(C) 2008 Southern Medical Association